Causes of vacuolar interface dermatitis edit
| Main conditions[2] | Characteristics | Micrograph | Photograph |
| Generally/Not otherwise specified |
Typical findings, called "vacuolar interface dermatitis":[2]
- Mild inflammatory cell infiltrate along the dermoepidermal junction (black arrow in image)
- Vacuolization within the basal keratinocytes (white arrow in image)
- Often necrotic, predominantly basal, individual keratinocytes, manifesting as colloid or Civatte bodies
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| Acute graft-versus-host-disease |
- Vacuolar alteration of various severity, from focal or diffuse vacuolation of the basal keratinocytes (grade I), to separation at the dermoepidermal junction (grade III)
- Involvement of the hair follicle[2]
- Rarely eosinophils[2]
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| Allergic drug reaction |
- Rarely involvement of hair follicles.[2]
- Frequently eosinophils[2]
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| Lichen sclerosus |
Hyperkeratosis, atrophic epidermis, sclerosis of dermis and dermal lymphocytes.[3] |
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| Erythema multiforme |
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| Lupus erythematosis |
Typical findings in systemic lupus erythematosus:[4]
- Fibrinoid necrosis at the dermoepidermal junction
- Liquefactive degeneration and atrophy of the epidermis
- Mucin deposition in the reticular dermis
- Edema, small hemorrhages
- Mild and mainly lymphocytic infiltrate in the upper dermis
- Fibrinoid material in the dermis around capillary blood vessels, on collagen and in the interstitium
- In non-bullous cases, perivascular and interstitial neutrophils are sometimes present in the upper dermis, with damage to blood vessels
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An interface dermatitis with vacuolar alteration, not otherwise specified, may be caused by viral exanthems, phototoxic dermatitis, acute radiation dermatitis, erythema dyschromicum perstans, lupus erythematosus and dermatomyositis.[2]
