Valine N-monooxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Valine N-monooxygenase (EC 1.14.14.38, CYP79D1, CYP79D2) is an enzyme with systematic name L-valine,NADPH:oxygen oxidoreductase (N-hydroxylating).[1]This enzyme catalyses the following sequence of chemical reactions:
-2-methylpropanal_oxime.svg)
| Valine N-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.38 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme uses molecular oxygen and reduced nicotinamide adenine dinucleotide phosphate (NADPH) to convert L-valine first to its N-hydroxy derivative and then to N,N-dihydroxy-L-valine. This compound is unstable and loses carbon dioxide and water to give the (E) isomer of 2-methylpropanal oxime.[2]
Valine N-monooxygenase is a cytochrome P450 protein containing heme.[3] The product oxime is an intermediate in the biosynthesis of linamarin in Lotus japonicus.[2]
