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Valine dehydrogenase (NAD+)

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Valine dehydrogenase (NAD+) (EC 1.4.1.23) is an enzyme with systematic name L-valine:NAD+ oxidoreductase (deaminating).[1][2] This enzyme catalyses the following chemical reaction

2D representation of the chemical structure of Valine .
Valine
+ NAD+
 
 
H2O
H+
Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left
H2O
H+
 
2D representation of the chemical structure of α-Ketoisovaleric acid .
α-Ketoisovaleric acid
+ NADH + NH3
 
EC no.1.4.1.23
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Valine dehydrogenase (NAD+)
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EC no.1.4.1.23
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The enzyme from Streptomyces spp. uses nicotinamide adenine dinucleotide as its cofactor but has no activity with NADP+.[3]

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