Van Wyk and Grumbach syndrome
From Wikipedia, the free encyclopedia
| Van Wyk and Grumbach syndrome | |
|---|---|
| Other names | Van Wyk-Grumbach syndrome (VWGS) |
| Specialty | Endocrine |
Van Wyk and Grumbach syndrome is a medical condition defined by a combination of hypothyroidism, precocious puberty (with delayed bone age and lack of pubic hair), and ovarian cysts in pre- and post-pubertal girls or macroorchidism (unusually large testes) in boys.[1]
Symptoms are ascites, pleural and pericardial effusions, elevated ovarian tumour markers, enlarged pituitary gland and elevated prolactin and alpha-fetoprotein levels.[citation needed]
Mechanism
The presumed pathogenesis is that primary hypothyroidism causes enlargement and hyperstimulation of the pituitary gland which in turn cause ovarian hyperstimulation, ovarian cysts and precocious puberty.[citation needed]
Diagnosis
Diagnosis is made by imaging/sonography and thyroid hormone tests.[citation needed]