From 1994, Kassianidou taught Environmental Archaeology and Archaeometry at the Department of History and Archaeology of the University of Cyprus (UCy).[1] In 2022 she was elected as a Corresponding Member of the Archaeological Institute of America (AIA).[1] In May 2023 she was elected Dean of the Faculty of Letters at UCy.[7] From 2014 to 2023, Kassianidou was a member of the Board of Directors of the Cyprus National Commission for UNESCO.[1][4]
After the resignation of Michalis Hatzigiannis, Kassianidou was appointed Deputy Minister of Culture by President Nikos Christodoulides on 11 July 2023.[2][3][4][8] The Antiquities department fell under the Ministry of Culture from that month.[9]
In office, Kassianidou has visited the Hellenic Centre and the British Museum in London[10] and has discussed cultural cooperation opportunities with the Japanese ambassador.[11] Over 100,000 Cypriot cultural artifacts have been digitised as part of the Digitising the Museums of Cyprus project (CADiP).[12]
In December 2023, Kassianidou announced that Cyprus and seven other countries had "midwifery: knowledge, skills, and practices" registered on UNESCO's list of intangible culture heritage.[13] Also that month, the federation of theatre institutions called for her to resign as Deputy Minister over arts funding.[14]
In June 2025, an architecture booklet linked to Cyprus’ participation in the 19th International Architecture Biennale in Venice, Italy, was withdrawn after Kassianidou was referred to as a publisher of the book without her knowledge or consent.[15]
In February 2026, Kassianidou announced mosaic conservation and upgrades to the Tombs of the Kings at the archaeological site of Nea Paphos.[16]
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