Natoli was born in 1690 at Sant'Angelo di Brolo.[1]: 464 From 1730 to 1734, and again in 1740, he was a judge of the Gran Corte Criminale ("grand criminal court") of Palermo. From 10 April 1748 he was a minister in Messina. On 10 July 1751 he became a Regio Consultore, an advisor to the king in Naples. From 1758 he was president of the tribunal of the Real Patrimonio, or "royal heritage", in Palermo.[2]: 492 [3] He became president of the Civil and Criminal High Court in April 1761.[1]: 464
Natoli married Angela Piola and then, in 1748, he married the widowed daughter of Baron Mangiadaini, Maria Sieripopoli.[1]: 464 His son Artale Natoli pre-deceased him, dying on 11 December 1768.[3]: 492 Natoli died in Palermo on 21 October 1770 and was buried in the Catacombe dei Cappuccini in that city.[1]: 464