WAC (gene)

AliasesWAC, BM-016, PRO1741, Wwp4, DESSH, WW domain containing adaptor with coiled-coil

External IDsOMIM: 615049; MGI: 2387357; HomoloGene: 41148; GeneCards: WAC; OMA:WAC - orthologs

Chr.Chromosome 10 (human)^[1]

End28,623,112 bp^[1]

WAC
Identifiers
Aliases	WAC, BM-016, PRO1741, Wwp4, DESSH, WW domain containing adaptor with coiled-coil
External IDs	OMIM: 615049; MGI: 2387357; HomoloGene: 41148; GeneCards: WAC; OMA:WAC - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.1|10p12.1-p11.2 Start 28,532,493 bp[1] End 28,623,112 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 7,868,832 bp[2] End 7,929,028 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte Brodmann area 23 germinal epithelium caput epididymis tail of epididymis corpus epididymis parietal pleura superficial temporal artery amniotic fluid Top expressed in genital tubercle tail of embryo human fetus lateral septal nucleus ventromedial nucleus neural layer of retina body of femur ciliary body medullary collecting duct mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II complex binding chromatin binding protein binding Cellular component nuclear speck spliceosomal complex nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated histone monoubiquitination positive regulation of macroautophagy regulation of transcription, DNA-templated histone H2B conserved C-terminal lysine ubiquitination transcription, DNA-templated cellular response to DNA damage stimulus negative regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51322 225131 Ensembl ENSG00000095787 ENSMUSG00000024283 UniProt Q9BTA9 Q924H7 RefSeq (mRNA) NM_016628 NM_100264 NM_100486 NM_001146298 NM_001282093 NM_153085 NM_001360956 RefSeq (protein) NP_057712 NP_567822 NP_567823 NP_001139770 NP_001269022 NP_694725 NP_001347885 Location (UCSC) Chr 10: 28.53 – 28.62 Mb Chr 18: 7.87 – 7.93 Mb PubMed search [3] [4]
Wikidata
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WW domain-containing adapter protein with coiled-coil is a protein that in humans is encoded by the WAC gene.^[5][6]

The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known.^[6]