WAIFW matrix

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In infectious disease modelling, a who acquires infection from whom (WAIFW) matrix is a matrix that describes the rate of transmission of infection between different groups in a population, such as people of different ages.[1] Used with an SIR model, the entries of the WAIFW matrix can be used to calculate the basic reproduction number using the next generation operator approach.[2]

Assortative mixing

The WAIFW matrix for two groups is expressed as where Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "http://localhost:6011/en.wikipedia.org/v1/":): {\displaystyle \beta_{ij}} is the transmission coefficient from an infected member of group and a susceptible member of group . Usually specific mixing patterns are assumed.[citation needed]

Assortative mixing occurs when those with certain characteristics are more likely to mix with others with whom they share those characteristics. It could be given by [2] or the general WAIFW matrix so long as . Disassortative mixing is instead when .

Homogenous mixing

Homogenous mixing, which is also dubbed random mixing, is given by .[3] Transmission is assumed equally likely regardless of group characteristics when a homogenous mixing WAIFW matrix is used. Whereas for heterogenous mixing, transmission rates depend on group characteristics.

Asymmetric mixing

It need not be the case that . Examples of asymmetric WAIFW matrices are[4]

Social contact hypothesis

See also

References

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