WASF3

Wiskott–Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.^[5][6]

AliasesWASF3, Brush-1, SCAR3, WAVE3, WAS protein family member 3, WASP family member 3

External IDsOMIM: 605068; MGI: 2658986; HomoloGene: 68527; GeneCards: WASF3; OMA:WASF3 - orthologs

Chr.Chromosome 13 (human)^[1]

End26,688,948 bp^[1]

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WASF3
Identifiers
Aliases	WASF3, Brush-1, SCAR3, WAVE3, WAS protein family member 3, WASP family member 3
External IDs	OMIM: 605068; MGI: 2658986; HomoloGene: 68527; GeneCards: WASF3; OMA:WASF3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.13 Start 26,557,683 bp[1] End 26,688,948 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G3 Start 146,321,795 bp[2] End 146,410,425 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pars compacta pars reticulata paraflocculus of cerebellum lateral nuclear group of thalamus orbitofrontal cortex cerebellar vermis postcentral gyrus external globus pallidus Brodmann area 46 dorsal motor nucleus of vagus nerve Top expressed in ventral tegmental area neural layer of retina lobe of cerebellum cerebellar vermis dorsomedial hypothalamic nucleus mammillary body globus pallidus lateral hypothalamus lateral septal nucleus deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding Cellular component cytoplasm extracellular exosome cytoskeleton lamellipodium postsynapse glutamatergic synapse Biological process positive regulation of myelination oligodendrocyte development actin filament polymerization cytoskeleton organization actin cytoskeleton organization lamellipodium assembly regulation of cell shape protein-containing complex assembly modification of postsynaptic actin cytoskeleton Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10810 245880 Ensembl ENSG00000132970 ENSMUSG00000029636 UniProt Q9UPY6 Q5T8P4 Q8VHI6 RefSeq (mRNA) NM_001291965 NM_006646 NM_145155 RefSeq (protein) NP_001278894 NP_006637 NP_006637.2 NP_660137 Location (UCSC) Chr 13: 26.56 – 26.69 Mb Chr 5: 146.32 – 146.41 Mb PubMed search [3] [4]
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This gene encodes a member of the Wiskott–Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to transduce signals that involve changes in cell shape, motility or function.^[6]