WAY-317538

WAY-317538
Legal status
Legal status	In general: legal;
Identifiers
	IUPAC name 5-Morpholin-4-yl-pentanoic acid (4-pyridin-3-yl-phenyl)-amide;
CAS Number	874450-44-9 ;
PubChem CID	45484303; HCl: 45484302;
ChemSpider	24663034 ;
UNII	M92TU1EZ75;
ChEMBL	ChEMBL1084615 ; HCl: ChEMBL565540 ;
CompTox Dashboard (EPA)	DTXSID30670437 ;
Chemical and physical data
Formula	C20H25N3O2
Molar mass	339.439 g·mol−1
3D model (JSmol)	Interactive image; HCl: Interactive image;
	SMILES C3COCCN3CCCCC(=O)Nc1ccc(cc1)-c2cccnc2; ; HCl: C1COCCN1CCCCC(=O)NC2=CC=C(C=C2)C3=CN=CC=C3.Cl;
	InChI InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24) ; Key:XCHIZTUBUXZESJ-UHFFFAOYSA-N ; ; HCl: InChI=1S/C20H25N3O2.ClH/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18;/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24);1H; Key:GBMDUJQQSGOIFW-UHFFFAOYSA-N;
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WAY-317538 (SEN-12333) is a drug that acts as a potent and selective full agonist for the α7 subtype of neural nicotinic acetylcholine receptors. It was not the most potent compound in the series, but was selected for further development on the basis of its high selectivity over related receptors, ease of synthesis, and good in vivo properties including high oral bioavailability and good brain penetration.^[1] It has nootropic and neuroprotective effects in animal studies, and is being investigated as a potential treatment for neurodegenerative and neurocognitive conditions including Alzheimer's disease and schizophrenia.^[2]