WNT8B

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.^[5][6]

AliasesWNT8B, Wnt family member 8B

External IDsOMIM: 601396; MGI: 109485; HomoloGene: 2550; GeneCards: WNT8B; OMA:WNT8B - orthologs

Chr.Chromosome 10 (human)^[1]

End100,483,744 bp^[1]

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WNT8B
Identifiers
Aliases	WNT8B, Wnt family member 8B
External IDs	OMIM: 601396; MGI: 109485; HomoloGene: 2550; GeneCards: WNT8B; OMA:WNT8B - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.31 Start 100,463,009 bp[1] End 100,483,744 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 37.98 cM Start 44,481,911 bp[2] End 44,502,712 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas renal cortex human kidney right testis left testis olfactory zone of nasal mucosa granulocyte liver urinary bladder prostate Top expressed in corneal epithelium lumbar subsegment of spinal cord set of lens fibers vein ascending aorta embryo corneal endothelium aortic valve corneal stroma embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding frizzled binding receptor ligand activity Cellular component extracellular region extracellular space Biological process multicellular organism development cellular response to retinoic acid cell fate commitment determination of dorsal identity response to estradiol gastrulation response to retinoic acid neuron differentiation signal transduction nervous system development beta-catenin destruction complex disassembly Wnt signaling pathway regulation of signaling receptor activity canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7479 22423 Ensembl ENSG00000075290 ENSMUSG00000036961 UniProt Q93098 Q9WUD6 RefSeq (mRNA) NM_003393 NM_011720 RefSeq (protein) NP_003384 n/a Location (UCSC) Chr 10: 100.46 – 100.48 Mb Chr 19: 44.48 – 44.5 Mb PubMed search [3] [4]
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The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It encodes a protein showing 95%, 86%, and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.^[6]