WY-46824

WY-46824 is a norepinephrine-dopamine reuptake inhibitor related to venlafaxine. It was disclosed by Paige Mahaney and colleagues from Wyeth in 2008.^[1] The compound was mentioned in an earlier article from 2007 but was not the main focus of that study.^[2]

CAS Number

• 122718-49-4 ^Y

PubChem CID

• 10314993

ChemSpider

• 8490458

UNII

• 99T4HMN9HV

Quick facts Identifiers, CAS Number ...

WY-46824

Identifiers
IUPAC name 1-[1-(3-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexan-1-ol
CAS Number	122718-49-4 Y
PubChem CID	10314993
ChemSpider	8490458
UNII	99T4HMN9HV
ChEMBL	ChEMBL511347
CompTox Dashboard (EPA)	DTXSID50438031
Chemical and physical data
Formula	C19H29ClN2O
Molar mass	336.90 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CCN(CC1)CC(C2=CC(=CC=C2)Cl)C3(CCCCC3)O
InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3 Key:GRUIIAQNNWQJPW-UHFFFAOYSA-N

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WY-46824 has binding affinities of 46 nM for the norepinephrine transporter (NET), 58 nM for the dopamine transporter (DAT), and 18795 nM for the serotonin transporter (SERT). The racemic mixture of WY-46824 was resolved into its constituent enantiomers, with the (S)-enantiomer being the more active one. The N-desmethyl derivative of WY-46824 also shows similar activity.