Werewolf syndrome in dogs

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Structural formula of L-methionine sulfoximine

Canine werewolf syndrome is a neurological disorder caused by poisoning with methionine sulfoximine (MSO), a chemical compound from the sulfoximine group of substances. The disease was already observed in the first half of the 20th century[1], but fell into disuse with the discontinuation of flour bleaching with nitrogen trichloride (Agene process) from the 1950s onwards (ban in 1958), which produces methionine sulfoximine. From August to December 2024, there was an increase in cases in various European countries, starting in Finland and then spreading to Germany and other European countries. The trigger was certain batches of cattle bones imported from China, although it was never clarified how this substance got into chewing toys.[2]

Treatment

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