A chiral molecule is a molecular structure that is different from its mirror image. This property, while seemingly abstract, can have big consequences in biochemistry, where the shape of molecules is essential to their chemical function,[3] and where a chiral molecule can have very different biological activities from its mirror-image molecule.[4] When Topology Meets Chemistry concerns the mathematical analysis of molecular chirality.
The book has seven chapters, beginning with an introductory overview and ending with a chapter on the chirality of DNA molecules.[2]
Other topics covered through the book include the rigid geometric chirality of tree-like molecular structures such as tartaric acid, and the stronger topological chirality of molecules that cannot be deformed into their mirror image without breaking and re-forming some of their molecular bonds. It discusses results of Flapan and Jonathan Simon on molecules with the molecular structure of Möbius ladders, according to which every embedding of a Möbius ladder with an odd number of rungs is chiral while Möbius ladders with an even number of rungs have achiral embeddings. It uses the symmetries of graphs, in a result that the symmetries of certain graphs can always be extended to topological symmetries of three-dimensional space, from which it follows that non-planar graphs with no self-inverse symmetry are always chiral. It discusses graphs for which every embedding is topologically knotted or linked. And it includes material on the use of knot invariants to detect topological chirality.[1][2][4][5]
