Whiting reaction
Chemical reaction
From Wikipedia, the free encyclopedia
The Whiting reaction is an organic reaction converting a propargyl diol into a diene using lithium aluminium hydride.[1]
This organic reduction has been applied in the synthesis of fecapentaene, a suspected cause of colon cancer:[2]
Protecting groups are tetrahydropyranyl and TBSMS; the final step is deprotection with tetra-n-butylammonium fluoride.