William Vane, 1st Viscount Vane

At the 1708 British general election, Vane was returned unopposed as Member of Parliament for County Durham on his father's interest. He was active as a teller for various electoral disputes and voted for the naturalization of the Palatines, and for the impeachment of Dr Sacheverell. At the 1710 British general election, his father decided to drop him, so he did not stand.^[3]

In 1720 Vane was raised to the Peerage of Ireland as Baron Vane, of Dungannon in the County of Tyrone, and Viscount Vane.^[4] These titles did not disqualify him from sitting in the House of Commons. He succeeded his father in 1723.^[3]

At the 1727 British general election Vane was successfully returned in a contest for Steyning. At the 1734 British general election he was defeated at Steyning but returned in a contest as MP for Kent. However, he died suddenly only five days later.^[5]

In 1703, he married Lucy Joliffe, daughter of Sir William Joliffe, of Caverswall Castle, Staffordshire. The settlement, dated 15 November 1703, included Fairlawn, Kent, and lands in Durham, providing Vane with £600 p.a. for himself and his wife. After the marriage, Vane's father refused to include Fairlawn in the settlement, and took "great displeasure" and stopped the allowance when his son took legal advice. The case came before the House of Lords and the settlement was confirmed. Vane kept possession of Fairlawn.^[3] Together, they were the parents of:

• Christopher Vane, who predeceased Lord Vane.
• John Vane, who predeceased Lord Vane.
• William Vane, 2nd Viscount Vane (1714–1789), who married Frances, Lady William Hamilton who was previously married to the 4th Duke of Hamilton's second son, Lord William Hamilton.

Vane died of apoplexy on 20 May 1734 at Fairlawn, Shipbourne, Kent, where he was buried on 5 June. He was succeeded in the viscountcy by his only surviving son, William. Lady Vane died in March 1742.^[3]