In Semarang, he joined National Indische Partij. In 1921, he became a member of Semarang Gemeenteraad, representing Indische Partij. Wiwoho was also appointed as the chief of railroad workers and became a member of the Semarang railroad workers union.
Wiwoho moved to Yogyakarta in 1922 because the NIS office moved to Yogya and he lived there for five years. In 1925, Wiwoho and his colleagues founded a Muslim youth organization named Jong Islamieten Bond (JIB) and he was appointed as the vice chairman.[3] Two years after JIB was founded, he was designated as the chairman of Jong Islamieten Bond until 1928.[4] During his tenure as the chairman, JIB established a scouting organization, Nationale Indonesische Padvinderij.[4] In 1928, Wiwoho attended the second youth congress representing Jong Islamieten Bond.[5]
On 15 June 1931, Wiwoho became Volksraad member. He served at Volksraad until 1942. In 1937, Wiwoho was appointed as Volksraad's Working Committee member. As a member of Volksraad, Wiwoho proposed a motion that required a five-year transitional period before Indonesia became an independent country due to the political situation in Asia, and together with Mohammad Husni Thamrin and Soetardjo Kartohadikusumo, he filed a motion to the Dutch colonial government to replace the name of Dutch East India into Indonesia in August 1939. The Dutch East Indies Government rejected the latter motion. [7]
He also fought against any form of insulting Islam. On 29 July 1931, he protested Hoa Kiao magazine for writing an article that mocked Prophet Muhammad. His protest led to the demonstration of 6000 Muslims against the magazine in Surabaya. One month later, on 7 August 1931, Wiwoho complained about the article made by Jan ten Berge [nl] that offended Muslims.[8]
On 4 December 1938, Wiwoho, with his companions, founded the Indonesian Islamic Party and he was appointed as the party's chairman. Together with Wali Alfatah and Dr. Sukardi, Wiwoho is one of the three members of the PII board who was not from Muhammadiyah.[9]
During the Japanese occupation era, Wiwoho served as a member of the Central Advisory Council.
In 1945, he became the chairman of the Regional Leadership Council. Afterward, he was designated as Head of the Secretariat of Staff of Region V Military Government in Java. On 21 January 1950, Wiwoho was appointed as the Minister of Information Republic of Indonesia in the Halim Cabinet, replacing Raden Sjamsoeddin. He served as the minister of information until 6 September 1950.
Wiwoho was elected as a Yogyakarta Regional People's Representative Council member in 1951, representing the Masyumi Party[10] On 17 January 1952, Wiwoho was chosen as the speaker of the Yogyakarta Regional People's Representative Council through voting.[11] In 1956, Wiwoho was appointed as ambassador of Indonesia to Belgium. He served it until 1959.[12] In 1959, Wiwoho became a member of the People's Representative Council of Indonesia, replacing Prawoto Mangkusasmito.[13]
