8-hydroxyfuranocoumarin 8-O-methyltransferase
Class of enzymes
From Wikipedia, the free encyclopedia
8-hydroxyfuranocoumarin 8-O-methyltransferase (EC 2.1.1.70, furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, xanthotoxol 8-O-methyltransferase, XMT, SAM:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase, xanthotoxol methyltransferase, xanthotoxol O-methyltransferase, S-adenosyl-L-methionine:xanthotoxol O-methyltransferase, S-adenosyl-L-methionine-xanthotoxol O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase.[1][2][3] This enzyme catalyses the following general chemical reaction
- S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction)
| 8-hydroxyfuranocoumarin 8-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.70 | ||||||||
| CAS no. | 67339-13-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
For example, xanthotoxol is converted to methoxsalen:[4][5]
These are methylation reaction in which the methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).
