Xiyanping

1418130-80-9 ^Y
1443513-92-5^Y

Xiyanping
Identifiers

IUPAC name 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate
CAS Number	1418130-80-9 ^Y 1443513-92-5^Y
UNII	R4JE0B5I4U Z5RVW4Z10Q^Y

Xiyanping (喜炎平) is an anti-inflammatory and antiviral preparation developed and licensed for use in China. It is a semi-synthetic injectable product derived from the active component of the plant Andrographis paniculata (Chuan Xin Lian, 穿心蓮),^[1] which is used in Traditional Chinese medicine.^[2] Xiyanping is primarily composed of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate.^[3] It is used mainly in the treatment of hand, foot and mouth disease, diarrhea, upper respiratory tract infections and viral pneumonia,^[4]^[5]^[6]^[7] though one case report suggested it may also be useful in the treatment of Zika fever.^[8]

References

↑ Xiao XW, Fu HZ, Luo YH, Wei XY (2013). "Potential anti-angiogenic sulfates of andrographolide". Journal of Asian Natural Products Research. 15 (8): 809–18. doi:10.1080/10286020.2013.803473. PMID 23777373. S2CID 42522012.
↑ Chen JK, Chen TT (2012). "Chapter 2, Chuan Xin Lian". Chinese Medical Herbology and Pharmacology. Art of Medicine Press. pp. 214–215. ISBN 978-0-9740635-0-8.
↑ Chong L, Chen W, Luo Y, Jiang Z (July 2013). "Simultaneous determination of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate in rat plasma by UHPLC-ESI-MS/MS after administration of xiyanping injection: application to a pharmacokinetic study". Biomedical Chromatography. 27 (7): 825–30. doi:10.1002/bmc.2866. PMID 23355108.
↑ Zhang P, Xu H, Ling L, Wu X (2012). "Meta analysis of the efficacy of Xiyanping injection in the treatment of autumnal diarrhea in children". Pharmaceutical Care and Research. 12 (5): 349–353. doi:10.5428/pcar20120511 (inactive 12 July 2025).{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
↑ Wang J, Ren JX, Xie YM, Wang WW, Hu J, Liao X (September 2013). "[Systematic review of xiyanping injection for hand foot mouth disease]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica (in Chinese). 38 (18): 3215–22. PMID 24471354.
↑ Wang ZF, Chen X, Zhang W, Xie YM (September 2014). "[Literature review on premarketing and postmarketing evidence of xiyanping injection]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica (in Chinese). 39 (18): 3637–40. PMID 25532411.
↑ Sun SG, Shi YF, Yan H, Li Y, Wang R, Wang SH, Sun XD. Xiyanping Injection in Treatment of Viral Pneumonia in Children: A Meta-analysis of Random Control Trials. Chinese Herbal Medicines. 2015 May; 7(2):173-178. doi: 10.1016/S1674-6384(15)60035-1
↑ Deng Y, Zeng L, Bao W, Xu P, Zhong G (February 2016). "[Experience of integrated traditional Chinese and Western medicine in first case of imported Zika virus disease in China]". Zhonghua Wei Zhong Bing Ji Jiu Yi Xue (in Chinese). 28 (2): 106–9. doi:10.3760/cma.j.issn.2095-4352.2016.02.005. PMID 26911940.
↑ Wang ZF, Xiang YY, Xie YM (September 2013). "[Research on early warning signals of adverse drug reactions to parenterally administered xiyanping based on spontaneous reporting system (SRS) data]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica (in Chinese). 38 (18): 3008–12. PMID 24471321.
↑ See reference 2 above

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