YC8-02

Drug classSIRT2/3 inhibitor

PubChem CID

• 177378251

ChEMBL

• ChEMBL5595757

FormulaC₄₆H₆₃N₃O₂PS

YC8-02

Clinical data
Drug class	SIRT2/3 inhibitor
Identifiers
IUPAC name 2-[[(2S)-1-(3-hydroxyanilino)-1-oxo-6-(tetradecanethioylamino)hexan-2-yl]amino]ethyl-triphenylphosphanium
PubChem CID	177378251
ChEMBL	ChEMBL5595757
Chemical and physical data
Formula	C46H63N3O2PS
Molar mass	753.06 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCCCCCCCCCC(=S)NCCCC[C@@H](C(=O)NC1=CC(=CC=C1)O)NCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
InChI InChI=1S/C46H62N3O2PS/c1-2-3-4-5-6-7-8-9-10-11-21-34-45(53)48-35-23-22-33-44(46(51)49-39-25-24-26-40(50)38-39)47-36-37-52(41-27-15-12-16-28-41,42-29-17-13-18-30-42)43-31-19-14-20-32-43/h12-20,24-32,38,44,47H,2-11,21-23,33-37H2,1H3,(H2-,48,49,50,51,53)/p+1/t44-/m0/s1 Key:RIVWUGLXBPHZGR-SJARJILFSA-O

YC8-02 is a drug which acts as a potent inhibitor of the enzymes sirtuin 2 (SIRT2) and sirtuin 3 (SIRT3). It was developed from an older SIRT2 selective inhibitor thiomyristoyl, but substituted with a triphenylphosphine group which increases affinity to SIRT3 and selectively targets uptake into mitochondria. It is still relatively selective for SIRT2 with an IC₅₀ of 62nM at SIRT2 vs 530nM at SIRT3, but this still makes it one of the most potent SIRT3 inhibitors currently available. In animal studies it is useful for the treatment of certain forms of blood cancer such as lymphoma and leukemia.^[1][2][3]