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ZNF444

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene.[5]

AliasesZNF444, EZF-2, EZF2, ZSCAN17, zinc finger protein 444
End56,160,893 bp[1]
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ZNF444
Identifiers
AliasesZNF444, EZF-2, EZF2, ZSCAN17, zinc finger protein 444
External IDsOMIM: 607874; MGI: 1923365; GeneCards: ZNF444
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253792
NM_018337

NM_001146024
NM_028316

RefSeq (protein)

NP_001240721
NP_060807
NP_001240721.1

n/a

Location (UCSC)Chr 19: 56.13 – 56.16 MbChr 7: 6.18 – 6.2 Mb
PubMed search[3][4]
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Function

This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low-density lipoprotein (Ac-LDL) (Adachi H, Tsujimoto M (2002). "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J Biol Chem. 277 (27): 24014–21. doi:10.1074/jbc.M201854200. PMID 11978792.). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.

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