Zachary F. Mainen (born 20 February 1969, Bethesda, Maryland, United States of America) is an American neuroscientist whose research focuses on the brain mechanisms of decision-making.[1][2]
Mainen’s research explores brain function, especially decision-making, using theory-driven experimental approaches. His laboratory[3] helped to pioneer the use of quantitative behavioral paradigms in rodents and combines those approaches with electrophysiological, optical and genetic techniques to study neural representation and computation. He has a long-standing interest in the issue of how noise and uncertainty impact neural systems and behavior and our understanding of these processes. His lab is currently exploring these questions in the context of odor-guided perceptual decisions and learning, the timing and selection of simple actions, and the role of the neuromodulator serotonin in behavior and cortical function. This work touches on philosophical issues surrounding causality, free will, knowledge and belief.[2]