Zavondemstat

Zavondemstat (TACH101, QC8222) is a drug which acts as an inhibitor of the enzyme lysine-specific demethylase 4 (KDM4). It is described as a pan-KDM4 inhibitor, being active at all four isoforms KDM4A, KDM4B, KDM4C and KDM4D, which show functional redundancy so older inhibitors selective for just one isoform have failed to be effective. Zavondemstat is being researched for the treatment of certain forms of cancer and is in early stage clinical trials.^[1][2][3][4]

Drug classKDM4 inhibitor

CAS Number

• 1851412-93-5

PubChem CID

• 118597685

DrugBank

• DB21608

Quick facts Clinical data, Drug class ...

Zavondemstat

Clinical data
Drug class	KDM4 inhibitor
Identifiers
IUPAC name 3-[[(4R)-7-(N-methyl-4-propan-2-ylanilino)-3,4-dihydro-2H-chromen-4-yl]methylamino]pyridine-4-carboxylic acid
CAS Number	1851412-93-5
PubChem CID	118597685
DrugBank	DB21608
ChemSpider	128922294
UNII	4L3YJL2P4P
ChEMBL	ChEMBL5314494
Chemical and physical data
Formula	C26H29N3O3
Molar mass	431.536 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)C1=CC=C(C=C1)N(C)C2=CC3=C(C=C2)[C@@H](CCO3)CNC4=C(C=CN=C4)C(=O)O
InChI InChI=1S/C26H29N3O3/c1-17(2)18-4-6-20(7-5-18)29(3)21-8-9-22-19(11-13-32-25(22)14-21)15-28-24-16-27-12-10-23(24)26(30)31/h4-10,12,14,16-17,19,28H,11,13,15H2,1-3H3,(H,30,31)/t19-/m0/s1 Key:NDVITLLKZQXKGU-IBGZPJMESA-N

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