Zonampanel

Chemical compound From Wikipedia, the free encyclopedia

Zonampanel (INN, code name YM872) is a quinoxalinedione derivative drug and competitive antagonist of the AMPA receptor which was being investigated by Yamanouchi/Astellas Pharma as a neuroprotective drug for the treatment of ischemic stroke but never completed clinical trials.[1][2][3][4] In clinical trials, zonampanel produced severe side effects including hallucinations, agitation, and catatonia in patients, resulting in early termination of the trials.[5]

ATC code
  • None
CAS Number
PubChem CID
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Quick facts Clinical data, ATC code ...
Zonampanel
Skeletal formula
Space-filling model of zonampanel
Clinical data
ATC code
  • None
Identifiers
  • [7-(1H-Imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydro-1(2H)-quinoxalinyl]acetic acid
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H9N5O6
Molar mass331.244 g·mol−1
3D model (JSmol)
  • c1cn(cn1)c2cc3c(cc2[N+](=O)[O-])[nH]c(=O)c(=O)n3CC(=O)O
  • InChI=1S/C13H9N5O6/c19-11(20)5-17-8-4-9(16-2-1-14-6-16)10(18(23)24)3-7(8)15-12(21)13(17)22/h1-4,6H,5H2,(H,15,21)(H,19,20)
  • Key:SPXYHZRWPRQLNS-UHFFFAOYSA-N
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