Α-Methylmethcathinone

α-Methylmethcathinone (α-Me-MC), also known as βk-mephentermine or as RAD-081, is a norepinephrine–dopamine releasing agent (NDRA) of the amphetamine, cathinone, and phentermine families.^[1][2][3] It is the α-methyl analogue of methcathinone and the β-keto analogue of mephentermine.^[1][2][3] The drug's EC₅₀Tooltip half-maximal effective concentration values for induction of monoamine release are 153 nM for norepinephrine, 590 nM for dopamine, and 12,860 nM for serotonin in rat brain synaptosomes.^[1][2][3] α-Methylmethcathinone was first described in the scientific literature by 2019.^[1][2][3]

Other namesα,N-Dimethylcathinone; β-Keto-N-methylphentermine; β-Keto-α,N-dimethylamphetamine; β-Keto-α,α,N-trimethylphenethylamine; α-Methylmethcathinone; α-Me-MC; βk-Mephentermine; RAD-081; RAD081

Drug classNorepinephrine–dopamine releasing agent

CAS Number

• 1011-07-0

PubChem CID

• 22163342

Quick facts Clinical data, Other names ...

α-Methylmethcathinone

Clinical data
Other names	α,N-Dimethylcathinone; β-Keto-N-methylphentermine; β-Keto-α,N-dimethylamphetamine; β-Keto-α,α,N-trimethylphenethylamine; α-Methylmethcathinone; α-Me-MC; βk-Mephentermine; RAD-081; RAD081
Drug class	Norepinephrine–dopamine releasing agent
Identifiers
IUPAC name 2-methyl-2-(methylamino)-1-phenylpropan-1-one
CAS Number	1011-07-0
PubChem CID	22163342
Chemical and physical data
Formula	C11H15NO
Molar mass	177.247 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(C(=O)C1=CC=CC=C1)NC
InChI InChI=1S/C11H15NO/c1-11(2,12-3)10(13)9-7-5-4-6-8-9/h4-8,12H,1-3H3 Key:JLVGGPQTLAPRPH-UHFFFAOYSA-N

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