Α-PHiP

α-Pyrrolidinoisohexanophenone
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics); CA: Schedule I; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B;
Identifiers
	IUPAC name 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one;
CAS Number	2181620-71-1;
PubChem CID	59809191;
ChemSpider	68006957;
UNII	9AF2IHV9HK;
KEGG	C22829;
CompTox Dashboard (EPA)	DTXSID201337042 ;
Chemical and physical data
Formula	C16H23NO
Molar mass	245.366 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)CC(C(=O)c1ccccc1)N2CCCC2;
	InChI InChI=1S/C16H23NO/c1-13(2)12-15(17-10-6-7-11-17)16(18)14-8-4-3-5-9-14/h3-5,8-9,13,15H,6-7,10-12H2,1-2H3; Key:UOZWZANRCOALQL-UHFFFAOYSA-N;

α-Pyrrolidinoisohexanophenone (mainly known as A-PiHP or α-PiHP) is a stimulant drug of the cathinone class that has been sold online as a designer drug. It acts as a potent norepinephrine-dopamine reuptake inhibitor (NDRI). In July 2016 α-PiHP was first identified as a designer drug^[2] when it was reported to the EUDA by a forensic laboratory in Slovenia.^[3]^[4] It is a positional isomer of pyrovalerone, with the methyl group shifted from the 4-position of the aromatic ring to the 4-position of the acyl chain. Similarly to other cathinones, use of α-PiHP can result in compulsive redosing, addiction, anxiety, paranoia, and psychosis.