BCL6

El represor de la transcripción BCL6 (proteína 6 del linfoma de células B (BCL6)) es una proteína codificada en humanos por el gen bcl6.^[3]

PDBBúsqueda ortóloga: PDBe RCSB

AliasBCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell CLL/lymphoma 6, B cell CLL/lymphoma 6, transcription repressor, BCL6 transcription repressor

IDs externosOMIM: 109565 MGI: 107187 HomoloGene: 7640 GeneCards: BCL6

Función molecular

• sequence-specific DNA binding
• DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• intronic transcription regulatory region sequence-specific DNA binding
• chromatin binding
• metal ion binding
• GO:0001948, GO:0016582 unión a proteína plasmática
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• unión de ácido nucleico
• chromatin DNA binding
• identical protein binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific

Datos rápidos Estructuras disponibles, PDB ...

BCL6
Estructuras disponibles PDB Búsqueda ortóloga: PDBe RCSB Lista de codigos id de PDB 1R28, 1R29, 1R2B, 2EN2, 2EOS, 2LCE, 2YRM, 3BIM, 3E4U, 3LBZ, 4CP3, 4U2M
Identificadores
Alias	BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell CLL/lymphoma 6, B cell CLL/lymphoma 6, transcription repressor, BCL6 transcription repressor
IDs externos	OMIM: 109565 MGI: 107187 HomoloGene: 7640 GeneCards: BCL6
Ontología génica Función molecular • sequence-specific DNA binding • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • intronic transcription regulatory region sequence-specific DNA binding • chromatin binding • metal ion binding • GO:0001948, GO:0016582 unión a proteína plasmática • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • unión de ácido nucleico • chromatin DNA binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Componente celular • horquilla de replicación • núcleo celular • Nucleoplasma • aparato de Golgi Proceso biológico • regulation of germinal center formation • positive regulation of histone deacetylation • negative regulation of T-helper 2 cell differentiation • GO:0034613 protein localization • negative regulation of mast cell cytokine production • GO:0009373 regulation of transcription, DNA-templated • proceso del sistema inmunitario • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of cell differentiation • germinal center formation • negative regulation of Rho protein signal transduction • negative regulation of isotype switching to IgE isotypes • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • type 2 immune response • cellular response to DNA damage stimulus • negative regulation of cell-matrix adhesion • regulation of cell population proliferation • positive regulation of B cell proliferation • negative regulation of cell growth • Rho protein signal transduction • GO:0000767 cell morphogenesis • espermatogénesis • regulation of memory T cell differentiation • positive regulation of neuron differentiation • regulation of inflammatory response • regulation of immune response • positive regulation of apoptotic process • negative regulation of type 2 immune response • negative regulation of B cell apoptotic process • B cell differentiation • respuesta inflamatoria • GO:0045996 negative regulation of transcription, DNA-templated • actin cytoskeleton organization • negative regulation of cell population proliferation • negative regulation of Notch signaling pathway • erythrocyte development • negative regulation of cellular senescence • regulation of apoptotic process • negative regulation of mitotic cell cycle DNA replication • positive regulation of regulatory T cell differentiation • cytokine-mediated signaling pathway Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
Más referencias a datos de expressión
Ortólogos
Especies	Humano	Ratón
Entrez	604	12053
Ensembl	ENSG00000113916	ENSMUSG00000022508
UniProt	P41182	P41183
SeqRef (ARNm)	NM_001130845 NM_001134738 NM_001706 NM_138931	NM_009744 NM_001348026
SeqRef (proteina)	NP_001124317 NP_001128210 NP_001697	NP_001334955 NP_033874
Localización (UCSC)	n/a	n/a
Búsqueda en PubMed	[1]	[2]
Wikidata
Ver/Editar Humano		Ver/Editar Ratón

Cerrar

La proteína BCL6 es un factor de transcripción con un dominio de dedos de zinc y un dominio POZ en el dominio N-terminal. Esta proteína actúa como un represor de la transcripción específico de secuencia y se ha observado que regula la transcripción de los genes implicados en la respuesta de IL-4 dependiente de STAT en células B. BCL6 puede interaccionar con una variedad de proteínas con dominios POZ, actuando como un correpresor de la transcripción. El gen bcl6 se encuentra frecuentemente traslocado e hipermutado en patologías como el Linfoma difuso de células B grandes. Se han descrito dos variantes transcripcionales de este gen, que codifican la misma proteína.^[3]