Paeonol

Otros nombres 2'-Hydroxy-4'-methoxyacetophenone; 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one

Paeonol

Nombre IUPAC
1-(2-hydroxy-4-methoxyphenyl)ethanone
General
Otros nombres	2'-Hydroxy-4'-methoxyacetophenone; 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one
Fórmula estructural
Fórmula molecular	C₉H₁₀O₃
Identificadores
Número CAS	552-41-0^[1]
ChEBI	69581
ChEMBL	CHEMBL1079227
ChemSpider	10621
DrugBank	DB16830
PubChem	11092
UNII	3R834EPI82
SMILES CC(=O)C1=C(C=C(C=C1)OC)O
InChI InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3 Key: UILPJVPSNHJFIK-UHFFFAOYSA-N
Propiedades físicas
Masa molar	166,18 g/mol
Valores en el SI y en condiciones estándar (25 ℃ y 1 atm), salvo que se indique lo contrario.
[editar datos en Wikidata]

Paeonol con la fórmula química C₉H₁₀O₃, es un compuesto fenólico que se encuentra en la peonía como Paeonia suffruticosa y Paeonia officinalis,^[2]^[3] en Arisaema erubescens^[4] o en Dioscorea japonica.^[5] Se trata de un componente que se encuentra en muchos remedios de la medicina tradicional china.^[6]

Referencias

↑ Número CAS
1 2 Fukuhara Y and Yoshida D (1987). «Paeonol: a bio-antimutagen isolated from a crude drug, moutan cortex». Agricultural and biological chemistry 51 (5): 1441-1442. doi:10.1271/bbb1961.51.1441.
↑ Wu, Xinan; Chen, Hongli; Chen, Xingguo; Hu, Zhide (2003). «Determination of paeonol in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies following oral administration of Moutan cortex decoction». Biomedical Chromatography 17 (8): 504-8. PMID 14648606. doi:10.1002/bmc.259.
↑ Ducki S, Hadfield JA, Lawrence NJ, Xiuguo Zhang and McGown AT (1995). «Isolation of paeonol from Arisaema erubescens». Planta medica 61 (6): 586-587. PMID 8824957. doi:10.1055/s-2006-959390.
1 2 Miyazawa, Mitsuo; Shimamura, Hideo; Nakamura, Sei-Ichi; Kameoka, Hiromu (1996). «Antimutagenic Activity of (+)-β-Eudesmol and Paeonol fromDioscorea japonica». Journal of Agricultural and Food Chemistry 44 (7): 1647. doi:10.1021/jf950792u.
↑ Deng, Chunhui; Yao, Ning; Wang, Ben; Zhang, Xiangmin (2006). «Development of microwave-assisted extraction followed by headspace single-drop microextraction for fast determination of paeonol in traditional Chinese medicines». Journal of Chromatography A 1103 (1): 15-21. PMID 16309693. doi:10.1016/j.chroma.2005.11.023.
↑ Zhou, Jun; Zhou, Li; Hou, Deren; Tang, Jiaochun; Sun, Juanjuan; Bondy, Stephen C. (2011). «Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease». Brain Research 1388: 141-7. PMID 21377451. doi:10.1016/j.brainres.2011.02.064.
↑ Hsieh, Ching-Liang; Cheng, Chin-Yi; Tsai, Tung-Hu; Lin, I-Hsin; Liu, Chung-Hsiang; Chiang, Su-Yin; Lin, Jaung-Geng; Lao, Chih-Jui et al. (2006). «Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats». Journal of Ethnopharmacology 106 (2): 208-15. PMID 16458462. doi:10.1016/j.jep.2005.12.027.
↑ Chou, Tz-Chong (2003). «Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia». British Journal of Pharmacology 139 (6): 1146-52. PMC 1573952. PMID 12871833. doi:10.1038/sj.bjp.0705360.
↑ Kim, Sung Hoon; Kim, Seung-Ae; Park, Mi-Kyung; Kim, Seung-Hyung; Park, Young-Doo; Na, Ho-Jeong; Kim, Hyung-Min; Shin, Min-Kyu et al. (2004). «Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α». International Immunopharmacology 4 (2): 279-87. PMID 14996419. doi:10.1016/j.intimp.2003.12.013.
↑ Kong, L.D.; Cheng, Christopher H.K.; Tan, R.X. (2004). «Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones». Journal of Ethnopharmacology 91 (2–3): 351-355. PMID 15120460. doi:10.1016/j.jep.2004.01.013.

Referencias

Enlaces externos

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