Cladograma:[1]
--o Epitheria (McKenna, 1975)
|-o Leptictida McKenna, 1975 (†)
`-o Preptotheria (McKenna, 1975)
|-o Anagalida (Szalay & McKenna, 1971)
| |-o Macroscelidea (Butler, 1956) - musarañas-elefante
| |-o Duplicidentata (Illiger, 1811)
| | |-o Lagomorpha Brandt, 1855 - lagomorfos
| | `-o Mimotonida Li et al., 1987 (†)
| `-o Simplicidentata (Weber, 1904)
| |-o Mixodontia Sych, 1971 (†)
| `-o Rodentia Bowdich, 1821 - roedores
|-o Ferae (Linnaeus, 1758)
| |-o Carnivora Bowdich, 1821 - carnívoros
| |-o Cimolesta McKenna, 1975 - pangolines
| `-o Creodonta (Cope, 1875) (†)
|-o Lipotyphla (Haeckel, 1866)
| |-o Chrysochloridea Broom, 1915 - topos dorados
| |-o Erinaceomorpha (Gregory, 1910) - erizos y topos
| `-o Soricomorpha (Gregory, 1910) - musarañas y tenrecs
|-o Archonta (Gregory, 1910)
| |-o Chiroptera Blumenbach, 1779 - murciélagos
| |-o Primates Linnaeus, 1758 - primates
| `-o Scandentia (Wagner, 1855) - tupayas
`-o Ungulata (Linnaeus, 1766)
|-o Dinocerata Marsh, 1873 (†)
|-o Tubulidentata Huxley, 1872 - cerdo hormiguero
|-o Altungulata (Prothero & Schoch, 1989)
| |-o Perissodactyla Owen, 1848 - perisodáctilos
| `-o Uranotheria McKenna & Bell, 1997 - damanes, elefantes y sirenios
|-o Eparctocyona McKenna, 1975
| |-o Artiodactyla Owen, 1848 - artiodáctilos
| |-o Arctostylopida Cifelli et al., 1989 (†)
| |-o Cete Linnaeus, 1758 - cetáceos
| |-o Condylarthra Cope, 1881 (†)
| `-o Procreodi Matthew, 1915 (†)
`-o Meridiungulata McKenna, 1975 (†)
|-o Astrapotheria Lydekker, 1894 (†)
|-o Litopterna Ameghino, 1889 (†)
|-o Notoungulata Roth, 1903 (†)
|-o Pyrotheria Ameghino, 1895 (†)
`-o Xenungulata Paula Couto, 1952 (†)
