RANBP9

AliasRANBP9, Ranbp9, IBAP-1, Ibap1, RanBPM, BPM-L, BPM90, RanBP7, RAN binding protein 9

IDs externosOMIM: 603854 MGI: 1928741 HomoloGene: 38057 GeneCards: RANBP9

Función molecular

• enzyme binding
• GO:0001948, GO:0016582 unión a proteína plasmática

Componente celular

• citoplasma
• citosol
• membrana plasmática
• membrana
• núcleo celular
• microtubule associated complex
• ubiquitin ligase complex

RANBP9

Identificadores

Alias

RANBP9, Ranbp9, IBAP-1, Ibap1, RanBPM, BPM-L, BPM90, RanBP7, RAN binding protein 9

IDs externos

OMIM: 603854 MGI: 1928741 HomoloGene: 38057 GeneCards: RANBP9

Ontología génica
Función molecular	• enzyme binding • GO:0001948, GO:0016582 unión a proteína plasmática
Componente celular	• citoplasma • citosol • membrana plasmática • membrana • núcleo celular • microtubule associated complex • ubiquitin ligase complex
Proceso biológico	• negative regulation of ERK1 and ERK2 cascade • microtubule nucleation • Guía de axón • MAPK cascade • GO:0034622 protein-containing complex assembly
Fuentes: Amigo / QuickGO

Patrón de la expressión del ARN

Más referencias a datos de expressión

Ortólogos

Especies

Humano

Ratón

Entrez


10048


56705

Ensembl


ENSG00000010017


ENSMUSG00000038546

UniProt


Q96S59


P69566

SeqRef (ARNm)


NM_005493


NM_019930

SeqRef (proteina)


NP_005484


NP_064314 NP_001391577

Localización (UCSC)

n/a

Búsqueda en PubMed

^[1]

^[2]

Wikidata

Ver/Editar Humano

Ver/Editar Ratón

La proteína de unión a RAN 9 (RANBP9) es una proteína codificada en humanos por el gen ranbp9.^[3]^[4]^[5]

Este gen codifica una proteína que se une a RAN, una proteína que une GTP perteneciente a la superfamilia Ras esencial en la translocación de ARN y ciertas proteínas a través del poro nuclear hacia el núcleo celular. RANBP9 también ha demostrado interaccionar con otras proteínas como los proto-oncogenes c-Met, HIPK2, el receptor androgénico y Cdk11.^[5]

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ Nakamura M, Masuda H, Horii J, Kuma K, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T (Dec de 1998). «When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin». J Cell Biol 143 (4): 1041-52. PMC 2132962. PMID 9817760.
↑ Murrin LC, Talbot JN (Sep de 2007). «RanBPM, a scaffolding protein in the immune and nervous systems». J Neuroimmune Pharmacol 2 (3): 290-295. PMID 18040864.
1 2 «Entrez Gene: RANBP9 RAN binding protein 9».
↑ Wang, Dakun; Li Zaibo, Messing Edward M, Wu Guan (Sep. de 2002). «Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM». J. Biol. Chem. (United States) 277 (39): 36216-22. ISSN 0021-9258. PMID 12147692. doi:10.1074/jbc.M205111200.
↑ Zou, Yonglong; Lim Seunghwan, Lee Kangmoon, Deng Xiaobing, Friedman Eileen (Dec. de 2003). «Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M». J. Biol. Chem. (United States) 278 (49): 49573-81. ISSN 0021-9258. PMID 14500717. doi:10.1074/jbc.M307556200.
↑ Ideguchi, Haruko; Ueda Atsuhisa, Tanaka Masatsugu, Yang Jun, Tsuji Takashi, Ohno Shigeru, Hagiwara Eri, Aoki Akiko, Ishigatsubo Yoshiaki (Oct. de 2002). «Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM». Biochem. J. (England) 367 (Pt 1): 87-95. ISSN 0264-6021. PMID 12084015. doi:10.1042/BJ20011851.
↑ Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. de 2003). «DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation». Hum. Mol. Genet. (England) 12 (13): 1591-608. ISSN 0964-6906. PMID 12812986.
1 2 Rao, Mira A; Cheng Helen, Quayle Alandra N, Nishitani Hideo, Nelson Colleen C, Rennie Paul S (Dec. de 2002). «RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor». J. Biol. Chem. (United States) 277 (50): 48020-7. ISSN 0021-9258. PMID 12361945. doi:10.1074/jbc.M209741200.
↑ Emberley, Ethan D; Gietz R Daniel, Campbell J Darren, HayGlass Kent T, Murphy Leigh C, Watson Peter H (Nov. de 2002). «RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer». BMC Cancer (England) 2: 28. PMID 12421467.
↑ Wang, Ying; Marion Schneider E, Li Xin, Duttenhöfer Irina, Debatin Klaus, Hug Hubert (Sep. de 2002). «HIPK2 associates with RanBPM». Biochem. Biophys. Res. Commun. (United States) 297 (1): 148-53. ISSN 0006-291X. PMID 12220523.
↑ Umeda, M; Nishitani H; Nishimoto T (Jan. de 2003). «A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM». Gene (Netherlands) 303: 47-54. ISSN 0378-1119. PMID 12559565.

Referencias

Enlaces externos

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