Receptor de calcitonina

El receptor de calcitonina (CTR en inglés) es un receptor acoplado a proteínas G al que se une la hormona peptídica calcitonina y participa en el mantenimiento de la homeostasis del calcio,^[1] particularmente con respecto a la formación ósea y el metabolismo.^[2]^[3]^[4]

PDB Buscar ortólogos: PDBe, RCSB

Símbolo CALCR (HGNC: 1440)

Identificadores
externos

OMIM: 114131
EBI: CALCR

GeneCards: Gen CALCR

UniProt: CALCR

Locus Cr. 7

Datos rápidos Estructuras disponibles, PDB ...

Receptor de Calcitonina

Estructuras disponibles

PDB

Buscar ortólogos: PDBe, RCSB

Identificadores

Símbolo

CALCR (HGNC: 1440)

Identificadores
externos

OMIM: 114131
EBI: CALCR

GeneCards: Gen CALCR

UniProt: CALCR

Locus

Cr. 7

Ontología génica


Referencias: AmiGO / QuickGO

Ortólogos

Especies

Humano

Ratón

Entrez

799

UniProt

P30988

n/a

[editar datos en Wikidata]

Cerrar

PDB Buscar ortólogos: PDBe, RCSB

Símbolos CALCR (HGNC: 1440) CRT, CT-R, CTR, CTR1

Identificadores
externos

EBI: CALCR

GeneCards: Gen CALCR

UniProt: CALCR

Locus Cr. 7 q21.3

Datos rápidos CALCR, Estructuras disponibles ...

CALCR

Estructuras disponibles

PDB

Buscar ortólogos: PDBe, RCSB

Identificadores

Símbolos

CALCR (HGNC: 1440) CRT, CT-R, CTR, CTR1

Identificadores
externos

EBI: CALCR

GeneCards: Gen CALCR

UniProt: CALCR

Locus

Cr. 7 q21.3

Ontología génica


Referencias: AmiGO / QuickGO

Ortólogos

Especies

Humano

Ratón

Entrez

799

n/a

Ensembl

Véase HS

n/a

UniProt

P30988

-->

RefSeq
(ARNm)

NM_001742

n/a

RefSeq
(proteína) NCBI

NP_001158209

n/a

Ubicación (UCSC)

Cr. 7:
93.42 – 93.57 Mb

n/a

PubMed (Búsqueda)

[editar datos en Wikidata]

Cerrar

La CT funciona activando las proteínas G G_s y G_q que a menudo se encuentran en los osteoclastos, en las células del riñón y en las células de varias regiones del cerebro.^[5] También puede afectar los ovarios en las mujeres y los testículos en los hombres.

La función de la proteína del receptor CT se modifica a través de su interacción con las proteínas modificadoras de la actividad del receptor(RAMPs), formando los receptores de amilina multimérica AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), y AMY3 (CT + RAMP3).^[6]

Interacciones

Se ha demostrado que el receptor de calcitonina interactúa con la apolipoproteína B^[7]^[8] y LRP1.^[9]

Referencias

Lecturas adicionales

Pondel M (December 2000). «Calcitonin and calcitonin receptors: bone and beyond». International Journal of Experimental Pathology 81 (6): 405-22. PMC 2517743. PMID 11298188. doi:10.1046/j.1365-2613.2000.00176.x.
Gorn AH, Lin HY, Yamin M, Auron PE, Flannery MR, Tapp DR, Manning CA, Lodish HF, Krane SM, Goldring SR (November 1992). «Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line». The Journal of Clinical Investigation 90 (5): 1726-35. PMC 443230. PMID 1331173. doi:10.1172/JCI116046.
Albrandt K, Brady EM, Moore CX, Mull E, Sierzega ME, Beaumont K (December 1995). «Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene». Endocrinology 136 (12): 5377-84. PMID 7588285. doi:10.1210/en.136.12.5377.
Egerton M, Needham M, Evans S, Millest A, Cerillo G, McPheat J, Popplewell M, Johnstone D, Hollis M (April 1995). «Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization». Journal of Molecular Endocrinology 14 (2): 179-89. PMID 7619207. doi:10.1677/jme.0.0140179.
Nussenzveig DR, Mathew S, Gershengorn MC (May 1995). «Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor». Endocrinology 136 (5): 2047-51. PMID 7720653. doi:10.1210/en.136.5.2047.
Nakamura M, Hashimoto T, Nakajima T, Ichii S, Furuyama J, Ishihara Y, Kakudo K (April 1995). «A new type of human calcitonin receptor isoform generated by alternative splicing». Biochemical and Biophysical Research Communications 209 (2): 744-51. PMID 7733946. doi:10.1006/bbrc.1995.1562.
Pérez Jurado LA, Li X, Francke U (1995). «The human calcitonin receptor gene (CALCR) at 7q21.3 is outside the deletion associated with the Williams syndrome». Cytogenetics and Cell Genetics 70 (3-4): 246-9. PMID 7789182. doi:10.1159/000134044.
Nussenzveig DR, Thaw CN, Gershengorn MC (November 1994). «Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes». The Journal of Biological Chemistry 269 (45): 28123-9. PMID 7961748.
Kuestner RE, Elrod RD, Grant FJ, Hagen FS, Kuijper JL, Matthewes SL, O'Hara PJ, Sheppard PO, Stroop SD, Thompson DL (August 1994). «Cloning and characterization of an abundant subtype of the human calcitonin receptor». Molecular Pharmacology 46 (2): 246-55. PMID 8078488.
Frendo JL, Pichaud F, Mourroux RD, Bouizar Z, Segond N, Moukhtar MS, Jullienne A (April 1994). «An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid». FEBS Letters 342 (2): 214-6. PMID 8143880. doi:10.1016/0014-5793(94)80503-2.
Masi L, Becherini L, Gennari L, Colli E, Mansani R, Falchetti A, Cepollaro C, Gonnelli S, Tanini A, Brandi ML (April 1998). «Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women». Biochemical and Biophysical Research Communications 245 (2): 622-6. PMID 9571205. doi:10.1006/bbrc.1998.8445.
Taboulet J, Frenkian M, Frendo JL, Feingold N, Jullienne A, de Vernejoul MC (December 1998). «Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women». Human Molecular Genetics 7 (13): 2129-33. PMID 9817931. doi:10.1093/hmg/7.13.2129.
Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM (July 1999). «Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product». Molecular Pharmacology 56 (1): 235-42. PMID 10385705.
Nishikawa T, Ishikawa H, Yamamoto S, Koshihara Y (September 1999). «A novel calcitonin receptor gene in human osteoclasts from normal bone marrow». FEBS Letters 458 (3): 409-14. PMID 10570950. doi:10.1016/S0014-5793(99)01176-X.
Beaudreuil J, Taboulet J, Orcel P, Graulet AM, Denne MA, Baudoin C, Jullienne A, De Vernejoul MC (July 2000). «Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement». Bone 27 (1): 161-8. PMID 10865224. doi:10.1016/S8756-3282(00)00305-7.
Wada S, Yasuda S, Nagai T, Maeda T, Kitahama S, Suda S, Findlay DM, Iitaka M, Katayama S (April 2001). «Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor». Endocrinology 142 (4): 1471-8. PMID 11250927. doi:10.1210/en.142.4.1471.
Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM (September 2001). «C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells». The Journal of Experimental Medicine 194 (6): 781-95. PMC 2195958. PMID 11560994. doi:10.1084/jem.194.6.781.
Nosaka Y, Tachi Y, Shimpuku H, Kawamura T, Ohura K (2002). «Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants». The International Journal of Oral & Maxillofacial Implants 17 (1): 38-43. PMID 11858573.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (December 2002). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899-903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.

Receptor de calcitonina

Interacciones

Referencias

Lecturas adicionales

Enlaces externos

Related Articles

Related Articles

«Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice»

«Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly»

«Calcitonin and calcitonin receptors: bone and beyond»

«Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line»

«C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells»

«Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences»

MESH Calcitonin Receptors. (en inglés).
Datos: Q14905625

Multimedia: Calcitonin receptor / Q14905625