Dynamine 2

DNM2
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	2YS1
Identifiants
Alias	DNM2
IDs externes	OMIM: 602378 MGI: 109547 HomoloGene: 90883 GeneCards: DNM2
Position du gène (humain)
Chr.	Chromosome 19 humain
Fin	10,833,488 bp
Position du gène (souris)
Chr.	Chromosome 9 (souris)
Fin	21,419,055 bp
Expression génique
	Fortement exprimé dans
	granulocyte; ; mucosa of transverse colon; ; skin of leg; ; poumon droit; ; upper lobe of left lung; ; rectum; ; skin of abdomen; ; body of stomach; ; apex of heart; ; muqueuse gastrique;
	Fortement exprimé dans
	granulocyte; ; corpuscule rénal; ; articulation talo-crurale; ; lèvre; ; aorte ascendante; ; tail of embryo; ; valve aortique; ; medullary collecting duct; ; endocardial cushion; ; secondary oocyte;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	liaison nucléotide; liaison de monoxyde d'azote synthétase; SH3 domain binding; phosphatidylinositol 3-kinase regulatory subunit binding; D2 dopamine receptor binding; GTP binding; liaison protéique; WW domain binding; liaison de complexe macromoléculaire; liaison enzymatique; activité hydrolase; protein kinase binding; GTPase activity; microtubule binding;
Composant cellulaire	endocytic vesicle membrane; cytosol; endosome; centrosome; appareil de Golgi; membrane postsynaptique; membrane; postsynaptic density; focal adhesion; photoreceptor inner segment; clathrin-coated endocytic vesicle; Golgi membrane; membrane plasmique; synapse; ruffle membrane; jonction cellulaire; trans-Golgi network; midbody; cône de croissance; perinuclear region of cytoplasm; clathrin-coated pit; phagocytic cup; microtubule; exosome; cytosquelette; noyau; lamellipode; prolongement cellulaire; vésicule cytoplasmique; phagocytic vesicle membrane; cytoplasme; mitochondrial membranes; axone; complexe macromoléculaire; épine dendritique; dendritic spine head; présynapse; postsynaptic endocytic zone membrane; glutamatergic synapse; postsynaptic density, intracellular component;
Processus biologique	negative regulation of membrane tubulation; G protein-coupled receptor internalization; positive regulation of phagocytosis; neuron projection morphogenesis; regulation of transcription, DNA-templated; endocytose; regulation of axon extension; ventricular septum development; antigen processing and presentation of exogenous peptide antigen via MHC class II; transferrin transport; response to light stimulus; cellular response to X-ray; positive regulation of nitric oxide biosynthetic process; cellular response to dopamine; regulation of nitric-oxide synthase activity; internalisation de récepteur; regulation of Rac protein signal transduction; negative regulation of transforming growth factor beta receptor signaling pathway; endocytose à récepteur; coronary vasculature development; régulation positive de la transcription dépendante de l'ADN; positive regulation of P-type sodium:potassium-exchanging transporter activity; aorta development; positive regulation of endocytosis; positive regulation of substrate adhesion-dependent cell spreading; regulation of Golgi organization; G2/M transition of mitotic cell cycle; macropinocytosis; spermatogenèse; positive regulation of apoptotic process; synaptic vesicle transport; cellular response to nitric oxide; positive regulation of lamellipodium assembly; Golgi to plasma membrane transport; cellular response to carbon monoxide; transduction de signal; response to cocaine; phagocytose; mitochondrial fission; dynamin family protein polymerization involved in mitochondrial fission; organisation d'une membrane; fusion de membranes; negative regulation of non-motile cilium assembly; synaptic vesicle budding from presynaptic endocytic zone membrane; synaptic vesicle endocytosis; regulation of synapse structure or activity; postsynaptic neurotransmitter receptor internalization; positive regulation of clathrin-dependent endocytosis;
	Sources:Amigo / QuickGO
Orthologues
	1785
	13430
	ENSG00000079805
	ENSMUSG00000033335
	P50570
	P39054
	NM_004945; NM_001005360; NM_001005361; NM_001005362; NM_001190716
NM_001039520; NM_001253893; NM_001253894; NM_007871; NM_001357718;
	NM_001357719; NM_001357721
	NP_001005360; NP_001005361; NP_001005362; NP_001177645; NP_004936
NP_001034609; NP_001240822; NP_001240823; NP_031897; NP_001344647;
	NP_001344648; NP_001344650
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La dynamine 2 est l'une des trois dynamines, famille de protéines cytoplasmiques associée aux clathrines et impliquée dans la formation de vésicules lors de l'endocytose. Son gène est le DNM2 situé sur le chromosome 19 humain.