EIF2AK4

EIF2AK4
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1UKX, 4OTN
Identifiants
Alias	EIF2AK4
IDs externes	OMIM: 609280 MGI: 1353427 HomoloGene: 40891 GeneCards: EIF2AK4
Position du gène (humain)
Chr.	Chromosome 15 humain
Fin	40,035,591 bp
Position du gène (souris)
Chr.	Chromosome 2 (souris)
Fin	118,305,715 bp
Expression génique
	Fortement exprimé dans
	anté-hypophyse; ; cellule de la moelle osseuse; ; stromal cell of endometrium; ; membrane synoviale; ; tibia; ; tendon calcanéen; ; Brodmann area 9; ; noyau accumbens; ; left uterine tube; ; noyau caudé;
	Fortement exprimé dans
	medullary collecting duct; ; secondary oocyte; ; primary oocyte; ; zygote; ; saccule; ; otic placode; ; cellule de Paneth; ; artère carotide externe; ; epithelium of lens; ; artère carotide interne;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	activité de transférase; liaison nucléotide; protein kinase activity; tRNA binding; activité kinase; protein serine/threonine kinase activity; liaison ARN; liaison ATP; eukaryotic translation initiation factor 2alpha kinase activity;
Composant cellulaire	cytoplasme; polysome; cytosolic ribosome;
Processus biologique	positive regulation of translational initiation in response to starvation; adaptive immune response; negative regulation of neuron differentiation; positive regulation of long-term synaptic potentiation; positive regulation of adaptive immune response; negative regulation of translational initiation in response to stress; negative regulation of translational initiation; phosphorylation; processus du système immunitaire; cellular response to UV; cellular response to amino acid starvation; negative regulation of CREB transcription factor activity; regulation of feeding behavior; apprentissage; neurodéveloppement; viral translation; neuron projection extension; phosphorylation des protéines; cellular response to cold; mémoire à long terme; defense response to virus; cellular response to leucine starvation; eiF2alpha phosphorylation in response to endoplasmic reticulum stress; induction by virus of host autophagy; protein autophosphorylation; cycle cellulaire; negative regulation by host of viral genome replication; viral process; regulation of translation; regulation of translational initiation; positive regulation of defense response to virus by host; T cell activation involved in immune response; DNA damage checkpoint signaling; regulation of translational initiation by eIF2 alpha phosphorylation;
	Sources:Amigo / QuickGO
Orthologues
	440275
	27103
	ENSG00000128829
	ENSMUSG00000005102
	Q9P2K8
	Q9QZ05
	NM_001013703
	NM_001177806; NM_013719; NM_001355383
	NP_001013725
	NP_001171277; NP_038747; NP_001342312
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

PDBRecherche d'orthologue : PDBe RCSB

AliasEIF2AK4

IDs externesOMIM: 609280 MGI: 1353427 HomoloGene: 40891 GeneCards: EIF2AK4

Chr.Chromosome 15 humain^[1]

L'EIF2AK4 (pour « Eukaryotic translation initiation factor 2-alpha kinase 4 »), aussi souvent appelé GCN2, est une enzyme de type kinase dont le gène est EIF2AK4 situé sur le chromosome 15 humain.

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[2]

[3]

[4]

EIF2AK4

En médecine

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