FADD

FADD
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	3OQ9, 1A1W, 1A1Z, 1E3Y, 1E41, 2GF5, 3EZQ
Identifiants
Alias	FADD, MORT1
IDs externes	OMIM: 602457 MGI: 109324 HomoloGene: 2836 GeneCards: FADD
Position du gène (humain)
Chr.	Chromosome 11 humain
Fin	70,207,390 bp
Expression génique
	Fortement exprimé dans
	granulocyte; ; tendon of biceps brachii; ; stromal cell of endometrium; ; mucosa of transverse colon; ; sang; ; parotide; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; epithelium of esophagus;
	n/a
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	identical protein binding; tumor necrosis factor receptor superfamily binding; death effector domain binding; caspase binding; liaison protéique; liaison de protéase; death receptor binding; tumor necrosis factor receptor binding; receptor serine/threonine kinase binding; liaison de complexe macromoléculaire;
Composant cellulaire	cytosol; radeau lipidique; ripoptosome; cell body; neuron projection; CD95 death-inducing signaling complex; membrane plasmique; death-inducing signaling complex; cytoplasme; noyau; complexe macromoléculaire;
Processus biologique	TRAIL-activated apoptotic signaling pathway; regulation of extrinsic apoptotic signaling pathway via death domain receptors; motor neuron apoptotic process; processus du système immunitaire; necroptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of necroptotic process; positive regulation of interleukin-8 production; positive regulation of type I interferon-mediated signaling pathway; cell surface receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; positive regulation of macrophage differentiation; defense response to virus; activation of cysteine-type endopeptidase activity; apoptotic signaling pathway; cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of transcription by RNA polymerase II; extrinsic apoptotic signaling pathway via death domain receptors; regulation of apoptotic process; death-inducing signaling complex assembly; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; transduction de signal; positive regulation of proteolysis; viral process; apoptose; positive regulation of activated T cell proliferation; extrinsic apoptotic signaling pathway; positive regulation of T cell mediated cytotoxicity; positive regulation of extrinsic apoptotic signaling pathway; thymus development; positive regulation of adaptive immune response; T cell differentiation in thymus; système immunitaire inné; spleen development; negative regulation of activation-induced cell death of T cells; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of interferon-gamma production; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; lymph node development; T cell homeostasis; response to cocaine; response to morphine; behavioral response to cocaine; regulation of necroptotic process; positive regulation of apoptotic process; toll-like receptor 3 signaling pathway; kidney development;
	Sources:Amigo / QuickGO
Orthologues
	8772
	14082
	ENSG00000168040
	ENSMUSG00000031077
	Q13158
	Q61160
	NM_003824
	NM_010175
	NP_003815
	NP_034305
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

PDBRecherche d'orthologue : PDBe RCSB

AliasFADD, MORT1

IDs externesOMIM: 602457 MGI: 109324 HomoloGene: 2836 GeneCards: FADD

Chr.Chromosome 11 humain^[1]

FADD (de l'anglais : Fas-Associated protein with Death Domain), également appelé MORT1, est une protéine humaine encodée par un gène présent dans la région 11q13.3 du chromosome 11 humain et impliquée dans différents processus dont l'apoptose extrinsèque, la nécroptose et la prolifération^[4].

FADD est une protéine adaptatrice, faisant le lien entre les récepteurs de mort (tels que FasR ou TRAIL-R2) et les caspases initiatrices 8 et 10 dans un complexe de haut poids moléculaire appelé DISC (Death-Inducing Signaling Complex)^[5].

[1]

[2]

[3]

[4]

[5]

FADD

Fonction

Apoptose extrinsèque

Nécroptose

Notes et références

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