FOXC2

FOXC2
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1D5V
Identifiants
Alias	FOXC2
IDs externes	OMIM: 602402 MGI: 1347481 HomoloGene: 21091 GeneCards: FOXC2
Position du gène (humain)
Chr.	Chromosome 16 humain
Fin	86,569,728 bp
Position du gène (souris)
Chr.	Chromosome 8 (souris)
Fin	121,845,634 bp
Expression génique
	Fortement exprimé dans
	veine cave; ; palpebral conjunctiva; ; artère poplitée; ; ganglion trigéminal; ; Tibial arteries; ; urètre; ; aorte ascendante; ; ganglion sensitif d’un nerf spinal; ; Descending thoracic aorta; ; cardiac muscle tissue of right atrium;
	Fortement exprimé dans
	arc aortique; ; aorte ascendante; ; cinquième métatarsien; ; corpuscule rénal; ; nerf optique; ; valve aortique; ; quatrième métatarsien; ; somite; ; Sclérotome; ; lumbar spinal ganglion;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	sequence-specific DNA binding; liaison ADN; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; liaison protéique; identical protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; chromatin DNA binding; promoter-specific chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Composant cellulaire	noyau; nucléoplasme; corps nucléaire;
Processus biologique	voie de signalisation Notch; Somitogenèse; embryonic skeletal system morphogenesis; skeletal system development; insulin receptor signaling pathway; ureteric bud development; regulation of transcription, DNA-templated; positive regulation of cell migration involved in sprouting angiogenesis; neural crest cell development; paraxial mesoderm formation; paraxial mesodermal cell fate commitment; ostéogenèse; lymphangiogenesis; collagen fibril organization; kidney development; glomerular mesangial cell development; heart morphogenesis; negative regulation of transcription by RNA polymerase II; cardiac muscle cell proliferation; lymph vessel development; transcription, DNA-templated; embryonic heart tube development; positive regulation of endothelial cell migration; régulation positive de la transcription dépendante de l'ADN; développent d'un organisme multicellulaire; ventricular cardiac muscle tissue morphogenesis; développement du cœur; blood vessel remodeling; vascular endothelial growth factor receptor signaling pathway; blood vessel development; positive regulation of vascular wound healing; artery morphogenesis; branching involved in blood vessel morphogenesis; glomerular visceral epithelial cell differentiation; response to hormone; embryonic viscerocranium morphogenesis; embryonic cranial skeleton morphogenesis; camera-type eye development; glomerular endothelium development; positive regulation of cell adhesion mediated by integrin; mesoderm development; regulation of organ growth; metanephros development; prolifération cellulaire; positive regulation of transcription by RNA polymerase II; negative regulation of apoptotic process involved in outflow tract morphogenesis; transcription by RNA polymerase II; différenciation cellulaire; regulation of transcription by RNA polymerase II; morphogenèse d'une structure anatomique; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologues
	2303
	14234
	ENSG00000176692
	ENSMUSG00000046714
	Q99958
	Q61850
	NM_005251
	NM_013519
	NP_005242
	NP_038547
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le FOXC2 (pour « Forkhead box protein C2 ») est une protéine de type facteur de transcription appartenant à la famille de protéines FOX. Son gène est le FOXC2 situé sur le chromosome 16 humain.