MDM4

MDM4
	Structure de la protéine MDM4. Basé sur l'identifiant PDB 2CR8.
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	2CR8, 2VJE, 2VJF, 2VYR, 3DAB, 3EQY, 3FDO, 3FE7, 3FEA, 3JZO, 3JZP, 3JZQ, 3LBJ, 3MQR, 3U15, 4RXZ, 2MWY, 2N06, 2N0W, 2N14, 2N0U
Identifiants
Alias	MDM4, murine double minute 4, MDMX
IDs externes	OMIM: 602704 MGI: 107934 HomoloGene: 1794 GeneCards: MDM4
Position du gène (humain)
Chr.	Chromosome 1 humain
Fin	204,558,120 bp
Position du gène (souris)
Chr.	Chromosome 1 (souris)
Fin	132,958,299 bp
Expression génique
	Fortement exprimé dans
	mamelon; ; ovocyte; ; epithelium of colon; ; os spongieux; ; skin of thigh; ; pylore; ; tendon calcanéen; ; nerf sural; ; cardia; ; péricarde;
	Fortement exprimé dans
	secondary oocyte; ; primary oocyte; ; zygote; ; tubercule génital; ; saccule; ; tail of embryo; ; granulocyte; ; neural layer of retina; ; otic placode; ; spermatocyte;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison enzymatique; liaison protéique; liaison ion métal; ubiquitin protein ligase activity; zinc ion binding;
Composant cellulaire	noyau; nucléoplasme;
Processus biologique	G0 to G1 transition; DNA damage response, signal transduction by p53 class mediator; protein stabilization; prolifération cellulaire; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; cellular response to hypoxia; negative regulation of protein catabolic process; negative regulation of cell population proliferation; Ubiquitination; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of signal transduction by p53 class mediator; protein deubiquitination; protein-containing complex assembly; heart valve development; atrioventricular valve morphogenesis; endocardial cushion morphogenesis; ventricular septum development; atrial septum development;
	Sources:Amigo / QuickGO
Orthologues
	4194
	17248
	ENSG00000198625
	ENSMUSG00000054387
	O15151; Q5T0Y2
	O35618
NM_001204171; NM_001204172; NM_001278516; NM_001278517; NM_001278518;
	NM_001278519; NM_002393
	NM_008575; NM_001302801; NM_001302802; NM_001302803; NM_001302804
NP_001191100; NP_001191101; NP_001265445; NP_001265446; NP_001265447;
	NP_001265448; NP_002384
	NP_001289730; NP_001289731; NP_001289732; NP_001289733; NP_032601
	Wikidata
Voir/Editer Humain	Voir/Editer Souris