MIF (biologie)

MIF
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1CA7, 1CGQ, 1GCZ, 1GD0, 1GIF, 1LJT, 1MIF, 1P1G, 2OOH, 2OOW, 2OOZ, 3B9S, 3CE4, 3DJH, 3DJI, 3HOF, 3IJG, 3IJJ, 3JSF, 3JSG, 3JTU, 3L5P, 3L5R, 3L5S, 3L5T, 3L5U, 3L5V, 3SMB, 3SMC, 3U18, 4ETG, 4EUI, 4EVG, 4F2K, 4GRN, 4GRO, 4GRP, 4GRQ, 4GRR, 4GRU, 3WNR, 3WNS, 3WNT, 4K9G, 4OSF, 4OYQ, 4P01, 4P0H, 4WR8, 4WRB, 4PKZ, 4PLU, 4TRF, 4TRU, 4XX7, 4XX8, 5BS9, 5BSC, 5BSI, 5EIZ, 5HVV, 5CG4, 5J7Q, 5BSJ, 5HVT, 4PKK, 5B4O, 5HVS, 5J7P
Identifiants
Alias	MIF
IDs externes	OMIM: 153620 MGI: 96982 HomoloGene: 55655 GeneCards: MIF
Nomenclature EC	5.3.3.12
Position du gène (humain)
Chr.	Chromosome 22 humain
Fin	23,895,227 bp
Position du gène (souris)
Chr.	Chromosome 10 (souris)
Fin	75,696,074 bp
Expression génique
	Fortement exprimé dans
	anté-hypophyse; ; right adrenal gland; ; renal cortex; ; left adrenal gland; ; gyrus frontal supérieur; ; Brodmann area 9; ; left adrenal cortex; ; C1 segment; ; right uterine tube; ; right adrenal cortex;
	Fortement exprimé dans
	embryon; ; embryon; ; otic placode; ; Vesicula otica; ; somite; ; maxillary prominence; ; paroi abdominale; ; mandibular prominence; ; épiblaste; ; migratory enteric neural crest cell;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	cytokine activity; isomerase activity; liaison protéique; chemoattractant activity; phenylpyruvate tautomerase activity; signaling receptor binding; dopachrome isomerase activity; liaison de protéase; cytokine receptor binding; identical protein binding;
Composant cellulaire	vésicule; gaine de myéline; nucléoplasme; région extracellulaire; surface cellulaire; exosome; cytoplasme; cytosol; secretory granule lumen; ficolin-1-rich granule lumen; milieu extracellulaire;
Processus biologique	positive regulation of protein phosphorylation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of MAP kinase activity; carboxylic acid metabolic process; positive regulation of chemokine (C-X-C motif) ligand 2 production; processus du système immunitaire; positive regulation of fibroblast proliferation; DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic process; negative regulation of mature B cell apoptotic process; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; protein homotrimerization; positive regulation of lipopolysaccharide-mediated signaling pathway; cell surface receptor signaling pathway; negative regulation of DNA damage response, signal transduction by p53 class mediator; regulation of cell population proliferation; positive regulation of arachidonic acid secretion; positive regulation of B cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of prostaglandin secretion involved in immune response; prostaglandin biosynthetic process; système immunitaire inné; negative regulation of myeloid cell apoptotic process; réponse inflammatoire; prolifération cellulaire; positive regulation of phosphorylation; positive regulation of myeloid leukocyte cytokine production involved in immune response; leukocyte migration; regulation of macrophage activation; positive regulation of protein kinase A signaling; positive chemotaxis; neutrophil degranulation; interleukin-12-mediated signaling pathway; negative regulation of macrophage chemotaxis; positive regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologues
	4282
	17319
	ENSG00000276701; ENSG00000240972
	ENSMUSG00000033307
	P14174
	P34884
	NM_002415
	NM_010798
	NP_002406; NP_002406.1
	NP_034928
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

PDBRecherche d'orthologue : PDBe RCSB

AliasMIF

IDs externesOMIM: 153620 MGI: 96982 HomoloGene: 55655 GeneCards: MIF

Nomenclature EC5.3.3.12

Le MIF (Macrophage migration inhibitory factor) est une protéine de type cytokine. Il a, entre autres, un rôle dans l'immunité avec une action protectrice sur les cellules cardiaques. Son gène est MIF situe sur le chromosome 22 humain.

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MIF (biologie)

En médecine

Notes et références

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