NOS3

NOS3
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 4D1P
Identifiants
Alias	NOS3, Nitric Oxyde Synthase 3
IDs externes	OMIM: 163729 MGI: 97362 HomoloGene: 504 GeneCards: NOS3
Position du gène (humain)
Chr.	Chromosome 7 humain
Fin	151,014,588 bp
Position du gène (souris)
Chr.	Chromosome 5 (souris)
Fin	24,589,472 bp
Expression génique
	Fortement exprimé dans
	rate; ; apex of heart; ; auricule de l'oreillette droite; ; upper lobe of left lung; ; left uterine tube; ; ventricule gauche; ; body of uterus; ; right lobe of thyroid gland; ; artère coronaire gauche; ; artère coronaire droite;
	Fortement exprimé dans
	ventricule droit; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; tunica media of zone of aorta; ; tissu adipeux blanc; ; endocardial cushion; ; tissu adipeux brun; ; muscle digastrique; ; septum interventriculaire; ; gastrula;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	FMN binding; actin monomer binding; flavin adenine dinucleotide binding; scaffold protein binding; arginine binding; tetrahydrobiopterin binding; liaison ion métal; fixation de la calmoduline; liaison protéique; heme binding; NADP binding; activité d'oxydoréductase; cadmium ion binding; nitric-oxide synthase activity; NADPH-hemoprotein reductase activity;
Composant cellulaire	cytoplasme; endocytic vesicle membrane; cytosol; appareil de Golgi; membrane; Golgi membrane; membrane plasmique; cavéole; cytosquelette; noyau; membrane d'une vésicule;
Processus biologique	negative regulation of muscle hyperplasia; ovulation from ovarian follicle; positive regulation of guanylate cyclase activity; nitric oxide biosynthetic process; regulation of systemic arterial blood pressure by endothelin; regulation of sodium ion transport; développement des poumons; negative regulation of blood pressure; removal of superoxide radicals; regulation of nitric-oxide synthase activity; mitochondrion organization; response to heat; in utero embryonic development; negative regulation of hydrolase activity; cell redox homeostasis; arginine catabolic process; response to fluid shear stress; regulation of blood pressure; negative regulation of platelet activation; blood vessel remodeling; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; angiogenèse; negative regulation of potassium ion transport; nitric oxide mediated signal transduction; negative regulation of calcium ion transport; smooth muscle hyperplasia; regulation of the force of heart contraction by chemical signal; endothelial cell migration; lipopolysaccharide-mediated signaling pathway; negative regulation of cell population proliferation; vasodilatation; positive regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; aortic valve morphogenesis; pulmonary valve morphogenesis; endocardial cushion morphogenesis; positive regulation of gene expression; homeostasis of number of cells within a tissue; ventricular septum morphogenesis; negative regulation of biomineral tissue development; response to hormone; response to lipopolysaccharide; regulation of nervous system process; positive regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologues
	4846
	18127
	ENSG00000164867
	ENSMUSG00000028978
	P29474
	P70313
	NM_000603; NM_001160109; NM_001160110; NM_001160111
	NM_008713
	NP_000594; NP_001153581; NP_001153582; NP_001153583
	NP_032739
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le NOS3 (pour « Nitric Oxyde Synthase 3 ») est une enzyme de type oxyde nitrique synthase exprimée au niveau de l'endothélium vasculaire. Son gène est NOS3 situé sur le chromosome 7 humain.

PDBRecherche d'orthologue : PDBe RCSB

AliasNOS3, Nitric Oxyde Synthase 3

IDs externesOMIM: 163729 MGI: 97362 HomoloGene: 504 GeneCards: NOS3

Chr.Chromosome 7 humain^[1]

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