PTPN22

PTPN22
	Structure de la protéine PTPN22. Basé sur l'identifiant PDB 2p6x.
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	2P6X, 2QCJ, 2QCT, 3BRH, 3H2X, 3OLR, 3OMH, 4J51
Identifiants
Alias	PTPN22, Protein tyrosine phosphatase, non receptor type 22
IDs externes	OMIM: 600716 MGI: 107170 HomoloGene: 7498 GeneCards: PTPN22
Position du gène (humain)
Chr.	Chromosome 1 humain
Fin	113,871,753 bp
Position du gène (souris)
Chr.	Chromosome 3 (souris)
Fin	103,819,563 bp
Expression génique
	Fortement exprimé dans
	cellule de la moelle osseuse; ; monocyte; ; granulocyte; ; buccal mucosa cell; ; sang; ; tendon calcanéen; ; artère temporale superficielle; ; ganglion lymphatique; ; epithelium of nasopharynx; ; rate;
	Fortement exprimé dans
	thymus; ; rate; ; granulocyte; ; ganglion lymphatique; ; ganglion mésentérique; ; zygote; ; sang; ; secondary oocyte; ; primary oocyte; ; morula;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	phosphoprotein phosphatase activity; SH3 domain binding; phosphatase activity; liaison de kinase; liaison protéique; activité hydrolase; ubiquitin protein ligase binding; protein tyrosine phosphatase activity;
Composant cellulaire	cytoplasme; perinuclear region of cytoplasm; cytoplasmic side of plasma membrane; noyau; cytosol;
Processus biologique	positive regulation of protein K63-linked ubiquitination; regulation of NIK/NF-kappaB signaling; regulation of innate immune response; regulation of natural killer cell proliferation; positive regulation of toll-like receptor 3 signaling pathway; regulation of T cell receptor signaling pathway; regulation of B cell receptor signaling pathway; phosphoanandamide dephosphorylation; processus du système immunitaire; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; negative regulation of p38MAPK cascade; protein dephosphorylation; negative regulation of gene expression; negative regulation of T cell receptor signaling pathway; cellular response to muramyl dipeptide; autophagie; response to lipopolysaccharide; T cell differentiation; positive regulation of gene expression; positive regulation of ERK1 and ERK2 cascade; positive regulation of toll-like receptor 4 signaling pathway; negative regulation of tumor necrosis factor production; negative regulation of autophagy; negative regulation of JUN kinase activity; negative regulation of T cell activation; positive regulation of type I interferon production; lipopolysaccharide-mediated signaling pathway; dephosphorylation; peptidyl-tyrosine dephosphorylation; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologues
	26191
	19260
	ENSG00000134242
	ENSMUSG00000027843
	Q9Y2R2
	P29352
	NM_001193431; NM_001308297; NM_012411; NM_015967
	NM_008979
	NP_001180360; NP_001295226; NP_036543; NP_057051
	NP_033005
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

PDBRecherche d'orthologue : PDBe RCSB

AliasPTPN22, Protein tyrosine phosphatase, non receptor type 22

IDs externesOMIM: 600716 MGI: 107170 HomoloGene: 7498 GeneCards: PTPN22

Chr.Chromosome 1 humain^[1]

PTPN22 pour « Protein tyrosine phosphatase, non receptor type 22 », est une protéine tyrosine phosphatase (LYP) exprimée dans les tissus lymphoïdes et codée par le gène PTPN22^[5] situé sur le chromosome 1 humain.

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[2]

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[4]

[5]

PTPN22

Rôles et fonctions de la protéine PTPN22

En médecine

Notes et références

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