TGFBR1

TGFBR1
	Structure de la protéine TGFBR1. Basé sur l'identifiant PDB 1b6c.
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1B6C, 1IAS, 1PY5, 1RW8, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J, 4X2K, 4X2N, 4X2G, 4X2F, 5E8W, 5E8X, 5E8U, 5E8T, 5E8S, 5E90, 5E8Z
Identifiants
Alias	TGFBR1
IDs externes	OMIM: 190181 MGI: 98728 HomoloGene: 3177 GeneCards: TGFBR1
Position du gène (humain)
Chr.	Chromosome 9 humain
Fin	99,154,192 bp
Position du gène (souris)
Chr.	Chromosome 4 (souris)
Fin	47,414,931 bp
Expression génique
	Fortement exprimé dans
	Veine saphène; ; tibia; ; pleura viscéral; ; tendon calcanéen; ; jointure synoviale; ; canal galactophore; ; ventricular zone; ; mucosa of paranasal sinus; ; éminence ganglionnaire; ; artère temporale superficielle;
	Fortement exprimé dans
	medullary collecting duct; ; ganglion cervical supérieur; ; cumulus cell; ; medial ganglionic eminence; ; mandibular prominence; ; efferent ductule; ; paroi abdominale; ; tunica media of zone of aorta; ; maxillary prominence; ; molaire;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	type II transforming growth factor beta receptor binding; I-SMAD binding; transforming growth factor beta-activated receptor activity; activité kinase; signaling receptor binding; liaison ATP; protein kinase activity; liaison ion métal; protein serine/threonine kinase activity; transforming growth factor beta receptor activity, type I; activité de transférase; growth factor binding; transmembrane receptor protein serine/threonine kinase activity; liaison protéique; SMAD binding; liaison nucléotide; transforming growth factor beta binding; activin binding;
Composant cellulaire	endosome; membrane; bicellular tight junction; surface cellulaire; radeau lipidique; integral component of membrane; receptor complex; membrane plasmique; jonction cellulaire; intracellulaire; intracellular membrane-bounded organelle; integral component of plasma membrane; activin receptor complex; noyau;
Processus biologique	skeletal system development; response to cholesterol; regulation of protein ubiquitination; développement postembryonnaire; phosphorylation des protéines; negative regulation of chondrocyte differentiation; mesenchymal cell differentiation; angiogenèse; transforming growth factor beta receptor signaling pathway; positive regulation of filopodium assembly; organisation d'une structure extracellulaire; pharyngeal system development; apoptose; cellular response to transforming growth factor beta stimulus; pathway-restricted SMAD protein phosphorylation; positive regulation of protein kinase B signaling; regulation of transcription, DNA-templated; kidney development; collagen fibril organization; thymus development; motilité d'une cellule; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of apoptotic signaling pathway; in utero embryonic development; negative regulation of transforming growth factor beta receptor signaling pathway; régulation positive de la transcription dépendante de l'ADN; développement du cœur; positive regulation of cell growth; parathyroid gland development; artery morphogenesis; blastocyst development; activin receptor signaling pathway; roof of mouth development; différenciation cellulaire; male gonad development; phosphorylation; skeletal system morphogenesis; cicatrisation; negative regulation of apoptotic process; Transition épithélio-mésenchymateuse; régulation de l'expression des gènes; embryonic cranial skeleton morphogenesis; peptidyl-threonine phosphorylation; intracellular signal transduction; positive regulation of endothelial cell proliferation; positive regulation of cell migration; regulation of epithelial to mesenchymal transition; positive regulation of pathway-restricted SMAD protein phosphorylation; endothelial cell activation; negative regulation of endothelial cell proliferation; transmembrane receptor protein serine/threonine kinase signaling pathway; lens development in camera-type eye; peptidyl-serine phosphorylation; positive regulation of cell population proliferation; régulation de la croissance; neuron fate commitment; regulation of protein binding; endothelial cell migration; germ cell migration; positive regulation of SMAD protein signal transduction; cardiac epithelial to mesenchymal transition; transduction de signal; anterior/posterior pattern specification; proepicardium development; ventricular trabecula myocardium morphogenesis; ventricular compact myocardium morphogenesis; positive regulation of epithelial to mesenchymal transition; protein deubiquitination; positive regulation of stress fiber assembly; regulation of cardiac muscle cell proliferation; ventricular septum morphogenesis; angiogenesis involved in coronary vascular morphogenesis; coronary artery morphogenesis; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of tight junction disassembly; epicardium morphogenesis; positive regulation of apoptotic process; positive regulation of gene expression; pattern specification process;
	Sources:Amigo / QuickGO
Orthologues
	7046
	21812
	ENSG00000106799
	ENSMUSG00000007613
	P36897
	Q64729
	NM_001130916; NM_001306210; NM_004612
	NM_009370; NM_001312868; NM_001312869
	NP_001124388; NP_001293139; NP_004603
	NP_001299797; NP_001299798; NP_033396
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

PDBRecherche d'orthologue : PDBe RCSB

AliasTGFBR1

IDs externesOMIM: 190181 MGI: 98728 HomoloGene: 3177 GeneCards: TGFBR1

Chr.Chromosome 9 humain^[1]

Le TGFBR1 (pour « Transforming growth factor, beta receptor I ») est l'une des deux protéines (avec le TGFBR2) constituant le récepteur au TGF-β. Son gène est le TGFBR1 situé sur le chromosome 9 humain.

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[4]

TGFBR1

En médecine

Notes et références

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