TLR3

TLR3
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Identifiants
Alias	TLR3, CD283
IDs externes	OMIM: 603029 MGI: 2156367 HomoloGene: 20696 GeneCards: TLR3
Position du gène (humain)
Chr.	Chromosome 4 humain
Fin	186,088,073 bp
Position du gène (souris)
Chr.	Chromosome 8 (souris)
Fin	45,864,117 bp
Expression génique
	Fortement exprimé dans
	muqueuse jéjunale; ; palpebral conjunctiva; ; placenta; ; rectum; ; sperme; ; duodénum; ; vésicule biliaire; ; tendon calcanéen; ; epithelium of colon; ; pancreatic epithelial cell;
	Fortement exprimé dans
	conjunctival fornix; ; gastrula; ; strie vasculaire; ; transitional epithelium of urinary bladder; ; vestibular membrane of cochlear duct; ; vestibular sensory epithelium; ; secondary oocyte; ; lumbar subsegment of spinal cord; ; Epithelium of choroid plexus; ; Jéjunum;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; identical protein binding; liaison ARN; liaison ARN double brin; transmembrane signaling receptor activity; signaling receptor activity;
Composant cellulaire	cytoplasme; integral component of membrane; endosome; membrane du réticulum endoplasmique; membrane; Golgi membrane; integral component of plasma membrane; intracellulaire; surface cellulaire; lysosomal membrane; early endosome; réticulum endoplasmique; endolysosome membrane; endosome membrane; milieu extracellulaire; matrice extracellulaire;
Processus biologique	positive regulation of interferon-beta production; response to dsRNA; réponse de défense; positive regulation of toll-like receptor signaling pathway; positive regulation of protein phosphorylation; male gonad development; positive regulation of inflammatory response; positive regulation of interleukin-12 production; positive regulation of type III interferon production; cellular response to interferon-beta; response to exogenous dsRNA; negative regulation of osteoclast differentiation; positive regulation of cytokine production; processus du système immunitaire; response to virus; activation of NF-kappaB-inducing kinase activity; I-kappaB phosphorylation; positive regulation of JNK cascade; hyperosmotic response; cellular response to dsRNA; regulation of dendritic cell cytokine production; microglial cell activation; toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; microglial cell activation involved in immune response; positive regulation of gene expression; defense response to bacterium; positive regulation of NF-kappaB transcription factor activity; defense response to virus; necroptotic signaling pathway; positive regulation of interleukin-8 production; cellular response to exogenous dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; cellular response to interferon-gamma; positive regulation of chemokine production; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; detection of virus; réponse inflammatoire; système immunitaire inné; I-kappaB kinase/NF-kappaB signaling; toll-like receptor 3 signaling pathway; positive regulation of type I interferon production; MyD88-independent toll-like receptor signaling pathway; transduction de signal; positive regulation of transcription by RNA polymerase II; Nécrose programmée; apoptotic signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; extrinsic apoptotic signaling pathway; positive regulation of angiogenesis; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologues
	7098
	142980
	ENSG00000164342
	ENSMUSG00000031639
	O15455
	Q99MB1
	NM_003265
	NM_126166; NM_001357316; NM_001357317
	NP_003256
	NP_569054; NP_001344245; NP_001344246
	Wikidata
Voir/Editer Humain	Voir/Editer Souris