TLR9

TLR9
Identifiants
Alias	TLR9
IDs externes	OMIM: 605474 MGI: 1932389 HomoloGene: 68126 GeneCards: TLR9
Position du gène (humain)
Chr.	Chromosome 3 humain
Fin	52,225,645 bp
Position du gène (souris)
Chr.	Chromosome 9 (souris)
Fin	106,104,082 bp
Expression génique
	Fortement exprimé dans
	sang; ; granulocyte; ; ganglion lymphatique; ; cellule de la moelle osseuse; ; rate; ; monocyte; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; muscle gastrocnémien; ; skeletal muscle tissue;
	Fortement exprimé dans
	zygote; ; gastrula; ; secondary oocyte; ; morula; ; granulocyte; ; muscle sterno-cléido-mastoïdien; ; rate; ; muscle digastrique; ; muscle temporal; ; thymus;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	liaison pARNi; interleukin-1 receptor binding; transmembrane signaling receptor activity; 1-phosphatidylinositol-3-kinase activity; protein homodimerization activity; unmethylated CpG binding; pattern recognition receptor activity;
Composant cellulaire	cytoplasme; integral component of membrane; endosome; membrane du réticulum endoplasmique; membrane; early phagosome; Golgi membrane; membrane plasmique; région extracellulaire; basolateral plasma membrane; apical plasma membrane; réticulum endoplasmique; phagocytic vesicle; endolysosome membrane; lysosome; endosome membrane; vésicule cytoplasmique; milieu extracellulaire; endolysosome;
Processus biologique	positive regulation of interleukin-18 production; positive regulation of toll-like receptor signaling pathway; positive regulation of inflammatory response; positive regulation of interleukin-12 production; axonogenesis; positive regulation of interleukin-10 production; processus du système immunitaire; positive regulation of JUN kinase activity; negative regulation of interleukin-6 production; I-kappaB phosphorylation; positive regulation of JNK cascade; positive regulation of nitric-oxide synthase biosynthetic process; MyD88-dependent toll-like receptor signaling pathway; negative regulation of interleukin-8 production; positive regulation of gene expression; negative regulation of ATPase-coupled calcium transmembrane transporter activity; negative regulation of toll-like receptor signaling pathway; defense response to bacterium; maintenance of gastrointestinal epithelium; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-8 production; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of chemokine production; tumor necrosis factor production; toll-like receptor 9 signaling pathway; système immunitaire inné; réponse inflammatoire; response to molecule of bacterial origin; negative regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; transduction de signal; positive regulation of interferon-beta production; toll-like receptor signaling pathway; phosphatidylinositol-3-phosphate biosynthetic process; positive regulation of immunoglobulin production; positive regulation of B cell proliferation; regulation of toll-like receptor 9 signaling pathway; positive regulation of MAPK cascade; regulation of B cell differentiation; positive regulation of B cell activation; positive regulation of NIK/NF-kappaB signaling; réponse immunitaire; I-kappaB kinase/NF-kappaB signaling; defense response to virus;
	Sources:Amigo / QuickGO
Orthologues
	54106
	81897
	ENSG00000239732
	ENSMUSG00000045322
	Q9NR96
	Q9EQU3
	NM_138688; NM_017442
	NM_031178
	NP_059138
	NP_112455
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le TLR9 (« Toll-like receptor 9 ») ou CD289 est une protéine de type récepteur de type Toll dont le gène TLR9 est situé sur le chromosome 3 humain. C'est le seul récepteur de type Toll a reconnaitre l' ADN. Il reconnait l'ADN dérivé d'un pathogène et également l'auto-ADN dérivé de l'hôte^[5].