BRCA2

BRCA2
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1N0W, 3EU7
識別子
記号	BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes
外部ID	OMIM: 600185 MGI: 109337 HomoloGene: 41 GeneCards: BRCA2
遺伝子の位置 (ヒト)
染色体	13番染色体 (ヒト)
終点	32,400,268 bp
遺伝子の位置 (マウス)
染色体	5番染色体 (マウス)
終点	150,493,794 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• DNA結合; • H4 histone acetyltransferase activity; • H3 histone acetyltransferase activity; • protease binding; • histone acetyltransferase activity; • 血漿タンパク結合; • gamma-tubulin binding; • single-stranded DNA binding; • protein C-terminus binding; • identical protein binding;
細胞の構成要素	• 中心体; • BRCA2-MAGE-D1 complex; • secretory granule; • 核質; • 微小管形成中心; • 細胞核; • 細胞骨格; • lateral element; • 細胞質; • 細胞質基質; • 高分子複合体;
生物学的プロセス	• chordate embryonic development; • ヌクレオチド除去修復; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • DNA recombination; • regulation of cytokinesis; • replication fork protection; • centrosome duplication; • male meiosis I; • negative regulation of mammary gland epithelial cell proliferation; • positive regulation of mitotic cell cycle; • 染色体構成; • 女性生殖腺発生; • inner cell mass cell proliferation; • positive regulation of transcription, DNA-templated; • telomere maintenance via recombination; • 脳発生; • oocyte maturation; • histone H3 acetylation; • 精子形成; • intrinsic apoptotic signaling pathway in response to DNA damage; • establishment of protein localization to telomere; • histone H4 acetylation; • DNA損傷刺激に対する細胞応答; • 細胞周期; • 細胞増殖; • response to gamma radiation; • response to UV-C; • response to X-ray; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • mitotic recombination-dependent replication fork processing; • double-strand break repair via homologous recombination; • DNA修復; • double-strand break repair; • mitotic cytokinesis; • 造血; • response to nutrient; • meiotic DNA repair synthesis involved in reciprocal meiotic recombination; • 乳房発達; • homologous chromosome orientation involved in meiotic metaphase I plate congression; • エストラジオールへの反応; • multicellular organism growth; • DNA synthesis involved in double-strand break repair via homologous recombination; • meiotic recombination checkpoint signaling;
	出典:Amigo / QuickGO
オルソログ
	675
	12190
	ENSG00000139618
	ENSMUSG00000041147
	P51587
	P97929
	NM_000059
	NM_001081001; NM_009765
	NP_000050
	NP_001074470; NP_033895
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

PDBオルソログ検索: RCSB PDBe PDBj

記号BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes

外部IDOMIM: 600185 MGI: 109337 HomoloGene: 41 GeneCards: BRCA2

染色体13番染色体 (ヒト)^[1]

BRCA2（[ˌbrækəˈtuː]、breast cancer susceptibility gene II、乳がん感受性遺伝子II)とは、がん抑制遺伝子の一種であり、その変異により遺伝子不安定性を生じ、最終的に乳癌を引き起こす。

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[2]

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[4]

BRCA2

病理

参考文献

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