HIF1A

HIF1A
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J
識別子
記号	HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α
外部ID	OMIM: 603348 MGI: 106918 HomoloGene: 1171 GeneCards: HIF1A
遺伝子の位置 (ヒト)
染色体	14番染色体 (ヒト)
終点	61,748,259 bp
遺伝子の位置 (マウス)
染色体	12番染色体 (マウス)
終点	73,994,304 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• protein dimerization activity; • DNA-binding transcription factor activity; • DNA-binding transcription activator activity, RNA polymerase II-specific; • ヒストンデアセチラーゼ結合; • 転写因子結合; • 酵素結合; • 血漿タンパク結合; • histone acetyltransferase binding; • プロテインキナーゼ結合; • Hsp90タンパク質結合; • sequence-specific DNA binding; • DNA結合; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • ubiquitin protein ligase binding; • protein heterodimerization activity; • E-box binding; • p53結合; • protein domain specific binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding;
細胞の構成要素	• 細胞質; • 細胞質基質; • 細胞核; • nuclear speck; • motile cilium; • transcription regulator complex; • RNA polymerase II transcription regulator complex; • axon cytoplasm; • 核質; • 核内構造体; • 高分子複合体;
生物学的プロセス	• negative regulation of neuron apoptotic process; • B-1 B cell homeostasis; • regulation of transforming growth factor beta2 production; • muscle cell cellular homeostasis; • outflow tract morphogenesis; • negative regulation of ossification; • heart looping; • negative regulation of TOR signaling; • 血管発生; • ヘモグロビン生合成プロセス; • 血管新生; • positive regulation of chemokine-mediated signaling pathway; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • positive regulation of hormone biosynthetic process; • negative regulation of mesenchymal cell apoptotic process; • regulation of aerobic respiration; • positive regulation of neuroblast proliferation; • dopaminergic neuron differentiation; • lactate metabolic process; • regulation of transcription, DNA-templated; • blood vessel morphogenesis; • positive regulation of erythrocyte differentiation; • glucose homeostasis; • vascular endothelial growth factor production; • regulation of thymocyte apoptotic process; • positive regulation of epithelial cell migration; • negative regulation of thymocyte apoptotic process; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • axonal transport of mitochondrion; • positive regulation of macroautophagy; • 軟骨形成; • positive regulation of nitric-oxide synthase activity; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • 授乳; • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; • positive regulation of pri-miRNA transcription by RNA polymerase II; • digestive tract morphogenesis; • 細胞分化; • neural fold elevation formation; • positive regulation of autophagy; • retina vasculature development in camera-type eye; • collagen metabolic process; • embryonic placenta development; • negative regulation of apoptotic process; • positive regulation of angiogenesis; • regulation of glycolytic process; • 上皮間葉転換; • 大脳皮質発生; • 遺伝子発現調節; • positive regulation of chemokine production; • intestinal epithelial cell maturation; • 触媒活性調節; • positive regulation of autophagy of mitochondrion; • cardiac ventricle morphogenesis; • response to muscle activity; • epithelial cell differentiation involved in mammary gland alveolus development; • visual learning; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • negative regulation of bone mineralization; • negative regulation of growth; • 低酸素症への反応; • positive regulation of endothelial cell proliferation; • regulation of transcription from RNA polymerase II promoter in response to oxidative stress; • iris morphogenesis; • mRNA transcription by RNA polymerase II; • hypoxia-inducible factor-1alpha signaling pathway; • 脈管構造発生; • regulation of cell population proliferation; • neural crest cell migration; • embryonic hemopoiesis; • connective tissue replacement involved in inflammatory response wound healing; • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; • negative regulation of reactive oxygen species metabolic process; • positive regulation of vascular endothelial growth factor production; • elastin metabolic process; • positive regulation of glycolytic process; • oxygen homeostasis; • シグナル伝達; • positive regulation of transcription by RNA polymerase II; • cellular iron ion homeostasis; • camera-type eye morphogenesis; • cellular response to hypoxia; • cellular response to interleukin-1; • transcription by RNA polymerase II; • protein deubiquitination; • 翻訳後修飾; • response to iron ion; • 遺伝子発現の負の調節; • positive regulation of blood vessel endothelial cell migration; • positive regulation of gene expression; • サイトカイン媒介シグナル伝達経路; • regulation of transcription by RNA polymerase II; • protein ubiquitination;
	出典:Amigo / QuickGO
オルソログ
	3091
	15251
	ENSG00000100644
	ENSMUSG00000021109
	Q16665,D0VY79,A8MYV6
	Q61221
	NM_181054; NM_001243084; NM_001530
	NM_010431; NM_001313919; NM_001313920
	NP_001230013; NP_001521; NP_851397; NP_001521.1
	NP_001300848; NP_001300849; NP_034561
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

HIF1Aはヘテロ二量体として構成される低酸素誘導因子HIF-1のうちHIF-1αサブユニットをコードしている遺伝子。^[5]^[6]^[7]

PDBオルソログ検索: RCSB PDBe PDBj

記号HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α

外部IDOMIM: 603348 MGI: 106918 HomoloGene: 1171 GeneCards: HIF1A

染色体14番染色体 (ヒト)^[1]

概要 PDBに登録されている構造, PDB ...

閉じる

[5]

[6]

[7]

[1]

[2]

[3]

[4]

HIF1A

脚注

参考文献

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