2001 Caribbean Series
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The forty-third edition of the Caribbean Series (Serie del Caribe) was held from February 1 through February 6 of 2001 with the champion baseball teams of the Dominican Republic, Águilas Cibaeñas; Mexico, Naranjeros de Hermosillo; Puerto Rico, Cangrejeros de Santurce, and Venezuela, Cardenales de Lara. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Estadio General Ángel Flores in Culiacán, Mexico.
| Country | Club | W | L | W/L % | Managers |
 Dominican Republic | Águilas Cibaeñas | 4 | 2 | .667 | Félix Fermín |
 Mexico | Naranjeros de Hermosillo | 3 | 3 | .500 | Derek Bryant |
.svg){kind=small} Venezuela | Cardenales de Lara | 3 | 3 | .500 | Nick Leyva |
 Puerto Rico | Criollos de Caguas | 2 | 4 | .333 | Sandy Alomar Sr. * |
* Had to attend family issues and was replaced by coach José López.