2025 Copa Sudamericana first stage

In the first stage, each tie was played on a single-leg basis, with the winner being decided in a penalty shoot-out in case of a draw after 90 minutes.^[3]

The 16 winners of the first stage advanced to the group stage to join the 12 teams directly qualified for that stage (six from Argentina and six from Brazil), and four teams transferred from the Copa Libertadores (the four teams eliminated in the third stage of qualifying).

Matches were played on 4–6 March 2025.^[7][8][9]

Team 1	Score	Team 2
Universitario de Vinto	0–1	Nacional Potosí
Aurora	0–1	GV San José
Universidad Católica	1–1 (4–5 p)	Palestino
Unión Española	2–2 (3–1 p)	Everton
Junior	2–2 (3–4 p)	América de Cali
Once Caldas	1–0	Millonarios
Mushuc Runa	2–1	Orense
Universidad Católica	0–0 (4–2 p)	Aucas
Sportivo Luqueño	2–0	Sportivo Ameliano
Guaraní	2–0	2 de Mayo
ADT	1–1 (5–6 p)	Cienciano
Atlético Grau	0–0 (4–2 p)	Cusco
Racing	0–0 (4–2 p)	Montevideo Wanderers
Cerro Largo	2–2 (4–3 p)	Danubio
Academia Puerto Cabello	3–0	Metropolitanos
Deportivo La Guaira	0–2	Caracas

4 March 2025 (2025-3-4)

20:30 UTC−4^{[note 1]}

Universitario de Vinto	0–1	Nacional Potosí
	Report	Camacho 31' (o.g.)

Estadio Félix Capriles, Cochabamba^{[note 2]}

Attendance: 1,047^[11]

Referee: Augusto Aragón (Ecuador)

Nacional Potosí advanced to the group stage (BOL 1).

5 March 2025 (2025-3-5)

18:00 UTC−4

Aurora	0–1	GV San José
	Report	Calero 62'

Estadio Félix Capriles, Cochabamba

Attendance: 3,870^[12]

Referee: José Cabero (Chile)

GV San José advanced to the group stage (BOL 2).

4 March 2025 (2025-3-4)

21:30 UTC−3

Universidad Católica	1–1	Palestino
Zampedri 88'	Report	Carrasco 11'
Penalties
Zampedri Jader Cuevas D. Valencia Ampuero	4–5	Martínez Tapia Meza Zúñiga Marabel

Estadio Municipal Francisco Sánchez Rumoroso, Coquimbo^{[note 3]}

Attendance: 2,706^[16]

Referee: Yael Falcón Pérez (Argentina)

Palestino advanced to the group stage (CHI 1).

5 March 2025 (2025-3-5)

19:00 UTC−3

Unión Española	2–2	Everton
Jeraldino 8' Aránguiz 45+1' (pen.)	Report	I. Ramírez 2', 81' (pen.)
Penalties
Uribe Suárez Carvallo Díaz	3–1	Baeza Moya Soto Piñeiro

Estadio Bicentenario de La Florida, Santiago^{[note 4]}

Attendance: 3,959^[18]

Referee: Paulo Zanovelli (Brazil)

Unión Española advanced to the group stage (CHI 2).

6 March 2025 (2025-3-6)^{[note 5]}

19:30 UTC−5

Junior	2–2	América de Cali
Paiva 54', 71'	Report	Lucumí 38' Vergara 44'
Penalties
González Barrera Rodríguez Báez Paiva	3–4	Quintero Holgado Soto Barrios Carrascal

Estadio Metropolitano Roberto Meléndez, Barranquilla

Attendance: 18,702^[20]

Referee: Wilton Sampaio (Brazil)

América de Cali advanced to the group stage (COL 1).

5 March 2025 (2025-3-5)

19:30 UTC−5

Once Caldas	1–0	Millonarios
Barrios 80'	Report

Estadio Palogrande, Manizales

Attendance: 26,535^[21]

Referee: Andrés Matonte (Uruguay)

Once Caldas advanced to the group stage (COL 2).

5 March 2025 (2025-3-5)

21:00 UTC−5

Mushuc Runa	2–1	Orense
Bentaberry 17' Simisterra 56'	Report	Achilier 39'

Estadio Olímpico Fernando Guerrero, Riobamba^{[note 6]}

Attendance: 2,989^[22]

Referee: Gery Vargas (Bolivia)

Mushuc Runa advanced to the group stage (ECU 1).

6 March 2025 (2025-3-6)

21:00 UTC−5

Universidad Católica	0–0	Aucas
	Report
Penalties
Cangá I. Díaz Martínez Cacciabue	4–2	Montenegro Jaramillo Porozo Almagro

Estadio Olímpico Atahualpa, Quito

Attendance: 4,070^[23]

Referee: Kevin Ortega (Peru)

Universidad Católica advanced to the group stage (ECU 2).

4 March 2025 (2025-3-4)^{[note 7]}

21:30 UTC−3

Sportivo Luqueño	2–0	Sportivo Ameliano
E. Vera 47' Ayala 86'	Report

Estadio Arsenio Erico, Asunción^{[note 8]}

Attendance: 2,003^[26]

Referee: Cristian Garay (Chile)

Sportivo Luqueño advanced to the group stage (PAR 1).

6 March 2025 (2025-3-6)

19:00 UTC−3

Guaraní	2–0	2 de Mayo
Mendieta 38' Torales 90+3'	Report

Estadio Arsenio Erico, Asunción^{[note 9]}

Attendance: 1,389^[29]

Referee: Gustavo Tejera (Uruguay)

Guaraní advanced to the group stage (PAR 2).

4 March 2025 (2025-3-4)

21:00 UTC−5

ADT	1–1	Cienciano
Cedrón 67'	Report	Choi 90+2' (o.g.)
Penalties
Choi Bersano Robles Cabello Fuentes Pérez Moyano	5–6	Garcés Cueva Valoyes Da Silva Estrada Neira Bolado

Estadio Huancayo, Huancayo^{[note 10]}

Attendance: 3,055^[30]

Referee: Derlis López (Paraguay)

Cienciano advanced to the group stage (PER 1).

6 March 2025 (2025-3-6)

19:30 UTC−5

Atlético Grau	0–0	Cusco
	Report
Penalties
Álvarez Rostaing Vásquez Olivares	4–2	Colman Colitto Ruidías Ampuero

Estadio Mansiche, Trujillo^{[note 11]}

Attendance: 0^{[note 12]}

Referee: Bryan Loayza (Ecuador)

Atlético Grau advanced to the group stage (PER 2).

5 March 2025 (2025-3-5)

19:00 UTC−3

Racing	0–0	Montevideo Wanderers
	Report
Penalties
Sosa Ferreira Pereira Severo	4–2	Veglio Lima T. Viudez Royón

Estadio Centenario, Montevideo^{[note 13]}

Referee: Roberto Pérez (Peru)

Racing advanced to the group stage (URU 1).

6 March 2025 (2025-3-6)

19:00 UTC−3

Cerro Largo	2–2	Danubio
Affonso 20', 45+6'	Report	Cardozo 49' S. Fernández 86' (pen.)
Penalties
Bertocchi Otormín Di Pippa Contrera	4–3	S. Fernández Millán Romero Femia Peralta

Estadio Arquitecto Antonio Eleuterio Ubilla, Melo

Attendance: 1,452^[33]

Referee: Alexis Herrera (Venezuela)

Cerro Largo advanced to the group stage (URU 2).

5 March 2025 (2025-3-5)^{[note 14]}

18:00 UTC−4

Academia Puerto Cabello	3–0	Metropolitanos
Manzambi 52' Padrón 90+1' Paredes 90+9'	Report

Estadio Misael Delgado, Valencia^{[note 15]}

Attendance: 5,111^[34]

Referee: Carlos Benítez (Paraguay)

Academia Puerto Cabello advanced to the group stage (VEN 1).

6 March 2025 (2025-3-6)

20:30 UTC−4

Deportivo La Guaira	0–2	Caracas
	Report	Echenique 23', 56'

Estadio Olímpico de la UCV, Caracas

Referee: Carlos Betancur (Colombia)

Caracas advanced to the group stage (VEN 2).