2C-O-22

2C-O-22, also known as 4-(2,2,2-trifluoroethoxy)-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families.^[1][2][3] According to Daniel Trachsel, 2C-O-22 produced potential threshold effects at a dose of 42 mg plus 15 mg orally, with Trachsel listing its dose as 57 mg or more.^[1][2] The drug's duration is unknown and its effects were not further described.^[1][2] The receptor interactions of 2C-O-22 have been studied, with it having been found to act as a serotonin 5-HT_2A receptor agonist among other actions.^[3] 2C-O-22 was first described in the scientific literature by Trachsel in 2012.^[2][1] It is a controlled substance in Canada under phenethylamine blanket-ban language.^[4]

Other names4-(2,2,2-Trifluoroethoxy)-2,5-dimethoxyphenethylamine; 2,5-Dimethoxy-4-(2,2,2-trifluoroethoxy)phenethylamine

Routes of
administrationOral^[1][2]

Drug classSerotonin receptor modulator; Serotonin 5-HT_2A receptor agonist; Serotonergic psychedelic; Hallucinogen

ATC code

• None

Quick facts Clinical data, Other names ...

2C-O-22

Clinical data
Other names	4-(2,2,2-Trifluoroethoxy)-2,5-dimethoxyphenethylamine; 2,5-Dimethoxy-4-(2,2,2-trifluoroethoxy)phenethylamine
Routes of administration	Oral[1][2]
Drug class	Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code	None
Pharmacokinetic data
Duration of action	Unknown[1]
Identifiers
IUPAC name 2-[2,5-dimethoxy-4-(2,2,2-trifluoroethoxy)phenyl]ethanamine
PubChem CID	57498514
Chemical and physical data
Formula	C12H16F3NO3
Molar mass	279.259 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=CC(=C(C=C1CCN)OC)OCC(F)(F)F
InChI InChI=1S/C12H16F3NO3/c1-17-9-6-11(19-7-12(13,14)15)10(18-2)5-8(9)3-4-16/h5-6H,3-4,7,16H2,1-2H3 Key:WXMPTDDEIHHBRM-UHFFFAOYSA-N

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