4-AcO-DET
Chemical compound
From Wikipedia, the free encyclopedia
4-AcO-DET, also known as 4-acetoxy-N,N-diethyltryptamine as well as ethacetin or ethylacybin, is a psychedelic tryptamine.[1][2]
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| Other names | 4-Acetoxy-DET; 4-Acetoxy-N,N-diethyltryptamine; Ethacetin; Ethylacybin |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
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| Duration of action | 3–6 hours[1][2] |
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| Formula | C16H22N2O2 |
| Molar mass | 274.364 g·mol−1 |
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Use and effects
4-AcO-DET is orally active, and doses of 10 to 25 mg are common.[1][2] Effects last 3 to 6 hours.[1][2] The free base is also active when smoked in a dose range of 5 to 20 mg.[2] Smoking 4-AcO-DET greatly speeds up the onset; peak effects are experienced within 10 minutes, and are usually over within 1 hour.[2]
Interactions
Pharmacology
It is expected that 4-AcO-DET is quickly hydrolyzed into the free phenolic 4-HO-DET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.[1][2]
Chemistry
History
4-AcO-DET was first synthesized by Albert Hofmann and Franz Troxler at Sandoz in 1958.[2]
Society and culture
Legal status
Canada
4-AcO-DET is not an explicitly nor implicitly controlled substance in Canada as of 2025.[3]
Finland
Listed in the "government decree on psychoactive substances banned from the consumer market".[4]
Sweden
Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-AcO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-acetoxi-N,N-dietyltryptamin (4-AcO-DET), making it illegal to sell or possess.[5]
United States
4-AcO-DET is not an explicitly controlled substance in the United States.[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
In consumer products
In December of 2025 the California department of public health issued a warning that products being sold as Magic Mushroom gummies chocolate bars and syrups contained 4-Aco-DET alongside 4-Aco-DMT.[7] They advised against consuming these products stating they may cause "severe illness, hospitalization, or even death". Severe adverse reactions such as extreme anxiety and vomiting have been reported from consumer products containing 4-Aco-DET from a variety of different brands.[8]