4-HO-DsBT

Chemical compound From Wikipedia, the free encyclopedia

4-HO-DsBT, also known as 4-hydroxy-N,N-di-sec-butyltryptamine, is a tryptamine derivative which acts as a serotonin receptor agonist.[1][2]

Other names4-HO-DSBT; 4-Hydroxy-N,N-di-sec-butyltryptamine
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4-HO-DsBT
Clinical data
Other names4-HO-DSBT; 4-Hydroxy-N,N-di-sec-butyltryptamine
Identifiers
  • 3-[2-[di(butan-2-yl)amino]ethyl]-1H-indol-4-ol
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Chemical and physical data
FormulaC18H28N2O
Molar mass288.435 g·mol−1
3D model (JSmol)
  • CCC(C)N(CCc1c[nH]c2cccc(O)c12)C(C)CC
  • InChI=1S/C18H28N2O/c1-5-13(3)20(14(4)6-2)11-10-15-12-19-16-8-7-9-17(21)18(15)16/h7-9,12-14,19,21H,5-6,10-11H2,1-4H3
  • Key:SMKFHUHBZWMALV-UHFFFAOYSA-N
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Use and effects

4-HO-DsBT was first made by Alexander Shulgin and is mentioned in his book TiHKAL (Tryptamines I Have Known and Loved), but was never tested by him.[1]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

It has been tested in vitro and unlike the n-butyl and isobutyl isomers which are much weaker, the s-butyl derivative retains reasonable potency, with a similar 5-HT2A receptor affinity to MiPT but better selectivity over the 5-HT1A and 5-HT2B subtypes.[2]

Chemistry

Analogues

Analogues of 4-HO-DsBT include 4-HO-DBT, 4-HO-DiBT, 4-HO-DtBT, 4-HO-DiPT, 4-HO-McPeT, 4-HO-PiPT, 5-MeO-DBT, dibutyltryptamine (DBT), and N-tert-butyltryptamine (NtBT), among others.

History

4-HO-DsBT was first described in the scientific literature by David Repke and colleagues by 1981.[3]

See also

References

External links

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