5,7-Dihydroxytryptamine

5,7-Dihydroxytryptamine (5,7-DHT) is a monoaminergic neurotoxin^[1][2] used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect is not well understood, but it is speculated to selectively destroy serotonergic neurons, in a manner similar to the dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA). What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimipramine (desipramine),^[3] which inhibits the norepinephrine transporter.

Quick facts Names, Identifiers ...

5,7-Dihydroxytryptamine

Names
Preferred IUPAC name 3-(2-Aminoethyl)-1H-indole-5,7-diol
Other names 5,7-Dihydroxytryptamine
Identifiers
CAS Number	31363-74-3 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL26726 Y
ChemSpider	32913 Y
ECHA InfoCard	100.045.977
EC Number	250-591-6
PubChem CID	35781
UNII	Y4K1D1H82S Y
CompTox Dashboard (EPA)	DTXSID00185285
InChI InChI=1S/C10H12N2O2/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14/h3-5,12-14H,1-2,11H2 Y Key: LXWHQTNFZDTKBH-UHFFFAOYSA-N Y InChI=1/C10H12N2O2/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14/h3-5,12-14H,1-2,11H2 Key: LXWHQTNFZDTKBH-UHFFFAOYAC
SMILES Oc1cc2c(c(O)c1)[nH]cc2CCN
Properties
Chemical formula	C10H12N2O2
Molar mass	192.214 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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